血浆同型半胱氨酸与中青年脑梗死关系的研究  

Study on the relationship between plasma homocysteine and ischemic stroke in young and middle-aged adults

作　　者：石炎川[1] 陈跃鸿[1] 原敏[2] 黄庆文[3] 吴瑞明[4] 杨妙雄[1] 郭婷辉[1] 陈文伙[1] 

机构地区：[1]福建医科大学附属漳州市医院神经内科,福建省漳州363000 [2]福建医科大学附属漳州市医院检验科,福建省漳州363000 [3]福建医科大学附属漳州市医院核磁共振室,福建省漳州363000 [4]福建医科大学附属漳州市医院彩超室,福建省漳州363000

出　　处：《中国基层医药》2012年第4期499-500,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察血浆同型半胱氨酸（Hcy）水平与中青年脑梗死的关系，探讨Hcy在中青年脑梗死发生、发展中的临床意义。方法应用循环酶法测定132例中青年脑梗死患者（观察组）及86例健康对照者的血浆Hey水平，并进行比较。结果观察组的血浆Hcy水平高于对照组[（24．32±5．68）、（12．58±3．53）μmol／L]，差异有统计学意义（t=17．26，P〈0．01）。血浆Hcy水平越高，急性期脑梗死的病灶越大，两者呈直线正相关关系（r=0．696，P〈0．01）。结论高同型半胱氨酸血症（HH）是中青年脑梗死的危险因素，血浆Hcy水平越高，急性期脑梗死的病灶越大；血浆Hcy水平能反映脑梗死灶的大小及病情程度；对有脑血管病倾向的中青年，血浆Hcy检查应作为常规检查或作为病情监测和预后判断的重要指标。Objective To observe the relationship between plasma level of homocysteine（HCY） and ischemic stroke in young and middle-aged adults, explore the clinical signficance concerning the occurrence and development of ischemic stroke in young and middle-aged adults. Methods The plasma homocysteine level of 132 young and middle-aged aduhs patients with ischemic and 86 control peoples were measured by means of enzymatic cycling assay. Results The plasma homocysteine level in ischemic stroke was higher than that in control group （ P 〈 0.01 ）. The higher the plasma homocysteine level, the larger infarcted focus in acute ischemic stroke group of young and middleaged adults. The plasma homocysteine level and the infarcted focus was positively linearly correlated. Conclusion Hyperhomocysteinemia is a risk factor of ischemic stroke among young and middle-aged adults. The higher the plasma homo cysteine level, the larger infarcted focus in acute ischemic stroke group. The plasma homocysteine level can reflect the size of the infarcted focus and the degree of disease ,and the plasma homocysteine level should serve as a kind of regular examination or as an index intervention can be taken, all of which are great importance to prevent ischemic stroke and reduce its morbilily .

关 键 词：半胱氨酸 脑梗死 中青年 

分 类 号：R743.3[医药卫生—神经病学与精神病学]