老年人不同类型脑梗死与血浆氧化型低密度脂蛋白、血糖、C-反应蛋白及白细胞介素6的关系  

Relationship between different types of acute ischemic stroke in elderly patients with serum OX-LDL, blood sugar, CRP and IL-6

作　　者：钟志强[1] 吴尉[2] 郑著家[2] 

机构地区：[1]大庆油田总医院神经内科,黑龙江省大庆163001 [2]大庆油田总医院消化内科,黑龙江省大庆163001

出　　处：《中国基层医药》2012年第4期517-519,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨老年人急性脑梗死患者血浆氧化型低密度脂蛋白（OX—LDL）、血糖、C-反应蛋白（CRP）和白细胞介素6（IL-6）水平变化及与不同类型急性脑梗死的关系。方法100例急性脑梗死患者（A组）及30例同期住院的非脑梗死健康患者（B组）行血浆OX．LDL、血糖、CRP、IL-6和颈动脉超声检查。并按低分子肝素试验TOAST病因分型标准分型，对不同类型脑梗死相关危险因素进行分析。结果A组OX—LDL、血糖、CRP和IL石分别为（627．2±174．7）μg/L、（8．8±1．7）mmol／L、（107．5±19．4）mg／L、（79．5±12．1）ng／L，均高于B组的（506.1±152．4）μg/L、（6．9±1．5）mmol／L、（87．2±13．6）mg/L、（58，5±10．3）ng/L（t=2．74，3．18，2．61，2．91，均P〈0．05）。结论老年人急性脑梗死与血浆OX—LDL、血糖、CRP和IL-6含量升高有关，且血浆OX—LDL增高易发大动脉粥样硬化型脑梗死，血糖增高发生小动脉闭塞型脑梗死的可能性大。Objective To investigate the relationship between different types of acute ischemic stroke in elderly patients and serum oxidized low-density hpoprotein （OX-LDL） ,blood sugar,C-reactive protein（CRP） and interleukin 6 （IL-6） levels. Methods 100 patients with acute cerebral infarction（ group A） and 30 heathy patients （group B） were investigated. The levels of serum OX-LDL, blood sugar, CRP and IL-6 were detected by automatic biochemical analysis. Results The levels of OX-LDL（627.2 ± 174.7 ） μg/L, blood sugar（ 8.8±1.7 ） retool/L, CRP （ 107.5± 19.4）mg/L and IL-6（79.5 ± 12.1 ）ng/L in patients of group A were significantly higher than group B[ OX-LDL （506.1± 152.4） μg/L, blood sugar（ 6.9±1.5 ） mmol/L, CRP （ 87.2 ± 13.6 ） mg/L and IL-6 （58.5 ± 10.3 ） ng/L ] （t =2.74,3.18,2.61,2.91,allP〈0.05）. Conclusion Elderly patients with acute cerebral infarction were closely related to the elevated levels of plasma OX-LDL, blood sugar, CRP and IL-6. Increased plasma OX-LDL was a risk factor for the main artery atherosclerosis type, and hyperglycemia was primary factor for the small artery atherosclerosis type of acute cerebral infarction.

关 键 词：脑梗死 低密度脂蛋白 血糖 C反应蛋白 白细胞介素6 老年人 

分 类 号：R743.33[医药卫生—神经病学与精神病学]