桑黄胞内及胞外多糖对荷瘤小鼠减毒增效作用的研究  

Decreasing toxicity and synergistic effects of intracellular and extracellular polysaccharides from Phellinus igniarius to tumor-bearing mice

作　　者：孟庆龙[1] 潘景芝[2] 陈丽[3] 刘福胜[3] 王琦[3] 

机构地区：[1]吉林省长春市南关区中医院,吉林长春130041 [2]吉林省长春市传染病医院,吉林长春130123 [3]吉林农业大学食药用菌教育部工程研究中心,吉林长春130118

出　　处：《中国中药杂志》2012年第6期847-852,共6页China Journal of Chinese Materia Medica

基　　金：长春净月经济开发区项目(20060529)

摘　　要：研究桑黄发酵产物中多糖对荷瘤小鼠的减毒增效作用。通过液体深层发酵技术获得桑黄菌丝体和发酵液,并从中提取胞内、外多糖PIP和PIE,并建立移植性S180肿瘤小鼠模型,分别观察环磷酰胺单用以及与桑黄发酵产物多糖联合应用时抑瘤率、胸腺指数、脾脏指数、体质量以及外周血细胞和IFN-γ含量的变化。结果表明桑黄发酵产物多糖可明显提高化疗小鼠的免疫功能,降低环磷酰胺的毒性,增强其抗肿瘤作用。To study the toxicity-decreasing and synergistic effect of intracellular and extracellular polysaccharides from Phellinus igniarius on S180 mice. The PIP and PIE were extracted from the products of liquid submerged fermentation of P. igniarius. Transplanting S180 mice tumor models were established so as to observe the changes in tumor inhibiting rate, indexes of the spleen and thymus, body weight, peripheral blood cells and IFN-y levels when CTX was used alone and when used in combination with the PIP and PIE from P. igniarius. The results indicate that the PIP and PIE fro,n P. igniarius can increase the activity of body immunity, attenuate the toxicity of CTX as well, and improve the anti-tumor effects.

关 键 词：深层发酵 荷瘤小鼠 IFN-Γ 环磷酰胺 

分 类 号：R285.5[医药卫生—中药学]