叶瓜参中的三个脑苷脂(英文)  

Three cerebrosides from the sea cucumber Cucumaria frondosa

作　　者：喇明平[1] 邵俊杰 焦健 易杨华[1] 

机构地区：[1]第二军医大学药学院海洋药物研究中心 [2]大连海晏堂生物有限公司

出　　处：《中国天然药物》2012年第2期105-109,共5页

基　　金：supported by International Science and Technology Cooperation Project of China (No.2010DFB30810)~~

摘　　要：目的:研究叶瓜参化学成分。方法:对叶瓜参的65%乙醇提取物中小极性部分进行行分离纯化,得到脑苷脂分子种3,对脑苷脂分子种3应用高效液相色谱进一步分离纯化,得到3个脑苷脂单体,CF-3-1(1)、CF-3-2(2)和CF-3-3(3)。结果:根据化合物的波谱数据和化学方法鉴定了其结构。结论:三个化合物为首次从叶瓜参中分离得到,首次得到化合物2和3的单体化合物。AIM： To study the chemical constituents of Monochasma savatierii Franch.. METHODS： The chemical constituents were isolated and repeatedly purified by column chromatography with silica gel, Rp-C18, Sephadex LH-20 and identified by IR, MS and NMR. RESULTS AND： Eight compounds were obtained and identified as 7, 8-dehydroboschnialactone （1）, argyol （2）, liquirti-genin （3）, β-sitosterol （4）, p-hydroxycinnamic acid （5）, 2-hydroxy-4-methoxybenzonic acid （6）, p-hydroxyphenylethanol （7）, proto-catechuic acid （8）. CONCLUSION： Compound 1 was obtained from natural source for the first time and the others have been isolated from this plant for the first time.

关 键 词：鞘糖脂 脑苷脂 海参 叶瓜参 

分 类 号：R284.1[医药卫生—中药学]