龋齿主要致病菌变形链球菌的生物免疫防治新进展  

New bio-immunologicai control progress of Streptococcus mutants： a major pathological bacterial against dental caries

作　　者：孙红武[1] 刘开云[1] 邹全明[1] 

机构地区：[1]中国人民解放军第三军医大学药学院微生物及生化药学教研室,重庆400038

出　　处：《国际免疫学杂志》2012年第2期113-117,共5页International Journal of Immunology

基　　金：中国人民解放军第三军医大学科技成果转化基金项目资助（2009XZH02）

摘　　要：世界卫生组织调查显示，在全球超过50亿人患过龋齿。龋齿已成为威胁人类口腔健康的全球性问题，而其主要致病菌变形链球菌的生物免疫防治研究如火如荼。到目前为止，在全球除奥丽汀健齿露外，还没其他任何预防龋齿的生物免疫防治产品上市和进入临床阶段。众所周知，大规模的生物免疫防治是治疗和预防龋齿的一种有效途径。了解近年来国内外在变形链球菌生物免疫防治中的主动防疫、被动免疫研究新进展研究可为后期研发出能进入临床试验，并能成功上市的龋齿生物免疫制剂提供指导意义和借鉴。World Health Organization surveys have shown that more than 5 billion people suffer from dental caries in the whole world. It has become a global oral health issue. A great deal of research have been carried about the bio-immunologieal control of streptococcus mutant, which was conformed as the major pathological bacteriam of dental caries. However, except Olitin Teeth Protection Spray, no other immune product to prevent dental caries comes into the market or the clinical trial stage until now. It is well known that the largescale biological immune is an effective way to prevent and treat the dental caries.

关 键 词：龋齿 变形链球菌 生物防治 主动免疫 被动免疫 

分 类 号：R781.1[医药卫生—口腔医学]