血管内皮生长因子-C和血管内皮生长因子受体-3在侵袭性甲状腺乳头状癌中的表达及意义  

The expression of VEGF-C and VEGFR3 in invasive papillary thyroid carcinoma and its significance

作　　者：李传乐[1] 张滨[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院普外四科,150086

出　　处：《国际免疫学杂志》2012年第2期157-159,共3页International Journal of Immunology

基　　金：哈尔滨医科大学第二临床医院博士启动基金项目（BS2007-18）

摘　　要：目的观察血管内皮生长因子（VEGF—C）和血管内皮生长因子受体（VEGFR5）在侵袭性甲状腺乳头状癌组织中的表达，探讨甲状腺乳头状癌细胞淋巴管转移机理。方法用免疫组化方法检测VEGF—C和VEGFR3在人侵袭性甲状腺乳头状癌和非侵袭性甲状腺乳头状癌中的表达情况，并进行比较和分析。结果在侵袭性和非侵袭性甲状腺乳头状癌中均可见到VEGF—C和VEGFR3阳性表达，但在侵袭性甲状腺乳头状癌组织VEGF—C（χ2=4．738，P=0．030）和VEGFR3（χ2=11．951，P=0．010）的表达率和表达强度均高于非侵袭性甲状腺乳头状癌。结论VEGF—C和VEGFR3在侵袭性甲状腺乳头状癌细胞中高表达，并且可能与此肿瘤的侵袭性相关。Objective The expression of vasular endothethlial a growth factors receptor（VEGF） -C and vascular endothe thlial growth factors receptor（VEGFR） 3 was observed in invasive papillary thyroid carcinoma in order to elucidate the mechanism of lymphatic metastasis of cancer cell. Methods The expression of VEGF- C and VEGFR3 in invasive and noninvasive papillary thyroid carcinoma was examined by immunohistochemical staining for comparison and analysis. Results Both VEGF-C （χ2 = 4. 738,P = 0.03 ） and VEGFR3 （χ2 = 11. 951 ,P =0. 01 ）expressed in invasive and noninvasive papillary thyroid carcinoma but were highly expressed in invasive papillary thyroid carcinoma. Conclusion The VEGF-C and VEGFR3 were highly expressed in invasire papillary thyroid carcinoma and perhaps have correlation with the invasiveness of cancer.

关 键 词：甲状腺乳头状癌 血管内皮生长因子-C 血管内皮生长因子受体-3 免疫组化 

分 类 号：R736.1[医药卫生—肿瘤]