溃疡性结肠炎活动期和缓解期中医症状分布特点的临床调查  

Clinical Investigation on Characteristics of TCM Symptom and Sign of UC in Acute Stage and Stable Stage

作　　者：陈剑明[1,2] 王天芳[1] 吴秀艳[1] 岳宏[1] 杨璐[1,3] 赵丹[1] 薛晓琳[1] 赵燕[1] 王庆国[1] 张声生[4] 王新月[2] 李军祥[5] 赵洪川[3] 苏娟萍[6] 邹小娟[7] 孙立亭[8] 刘冬梅[9] 赵文霞[10] 韩捷[11] 刘亚军[12] 邓鑫[13] 

机构地区：[1]北京中医药大学基础医学院,北京100029 [2]北京中医药大学东直门医院,北京100700 [3]卫生部中日友好医院,北京100029 [4]首都医科大学附属北京中医医院,北京100010 [5]北京中医药大学东方医院,北京100078 [6]山西省中医研究院附属山西省中医院,山西太原030012 [7]山东中医药大学附属医院,山东济南250011 [8]淄博市中心医院,山东淄博255036 [9]湖北中医药大学基础医学院,湖北武汉430065 [10]河南中医学院第一附属医院,河南郑州450000 [11]辽宁中医药大学附属医院,辽宁沈阳110032 [12]江苏省中医院,江苏南京210029 [13]广西中医学院附属瑞康医院,广西南宁530011

出　　处：《中华中医药学刊》2012年第3期497-500,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)资助项目(2003CB517101);北京中医药大学创新团队资助项目(2011-CXTD-08)

摘　　要：目的:通过全国多中心、大样本的临床调查,探讨溃疡性结肠炎中医症状分布特点。方法:采用课题组制定的溃疡性结肠炎临床信息采集表对符合病例选择标准的患者进行调查,建立Epidata 2.0临床调查资料数据库,运用SPSS 15.0软件对溃疡性结肠炎中医症状的频次、频率进行统计分析。结果:临床调查共收集溃疡性结肠炎951例,其中活动期829例,缓解期122例。症状分布特点:出现频率≥35%的症状在活动期有35个,缓解期有21个。活动期消化系统常见症状为泄泻、脓血便(血多于脓)、腹痛、腹胀、里急后重、肠鸣增多、矢气增多、肛门气坠、排便不爽、肛门灼热、泻下急迫;肠外症状为:乏力、神疲、畏寒、少气懒言、腰部酸软、下肢酸软、口苦、口咽干燥、纳呆、失眠、多梦、急躁易怒、烦躁、精神抑郁、胖大舌、齿痕舌、黄苔、腻苔、厚苔、燥苔、脉细、脉弦、脉滑。缓解期消化系统常见症状为腹痛、泄泻、里急后重、腹胀、排便不爽、肠鸣增多;肠外症状:齿痕舌、脉细、乏力、腻苔、胖大舌、口咽干燥、急躁易怒、白苔、淡白舌、畏寒、腰部酸软、神疲、脉沉、精神抑郁、少气懒言。结论:溃疡性结肠炎活动期和缓解期均以泄泻、腹痛、腹胀等为最常见,但全身症状的出现频率以活动期为多;本病的病机特点是虚实夹杂,但活动期以湿热蕴结大肠为主,兼有阳气不足之象,缓解期以脾肾阳气不足为主,兼有湿邪内阻之象。Objective ： To sum up the distribution characteristics of TCM symptoms of UC by a clinical investigation with large samples and different national centers. Methods ： By investigating the UC patients who comply with the case selection criteria by the ciinical information collection table established by RCPE, and establishing a literature data - base of terms of TCM symptoms, then analyze them by SPSS 15.0 software. Results ：951 cases altogether, included 829 cases of acute stage, and 122 cases in stable stage. The distribution characteristics of TCM Symptoms： frequency of symptoms is equal or greater and equal to 35% in active period has 35, and in remission there are 21. In acute stage, the common symptoms of digestive system are diarrhea, pus and blood stools （blood more than pus）, abdominal pain, abdominal distension, tenesmus, borborygmus increased, fart increased, dropping of the anus, unsmooth defecation, burning sensation in the anus, urgent diarrhea. The parenteral symptoms ： fatigue, shenpi, chills, disinclination to talk, weak waist, lower limb weakness, bitter taste in mouth, oropharynx drying, inappetence, insomnia, dreaminess, irritable and agitated, depression, fat tongue, tooth marks tongue, yellow coating, greasy coating, thick coating, dry coating, fine pulse, string pulse, slippery pulse. In stable stage, the common symptoms of digestive system are abdominal pain, diarrhea, tenesmus, abdominal distension, unsmooth defecation, borborygmus： increased. The parenteral symptoms ： tooth marks tongue, fine pulse, fatigue, greasy coating, fat tongue, oropharynx drying, irritable and agitated, white coating, shallow white tongue, chills, weak waist, shenpi, sink pulse, depression, disinclination to talk. Conclusion：The common symptoms of the patients with UC in both acute and stable stages are diarrhea, abdominal pain, abdominal distension. And frequency of the symptoms＇occurence of acute stage is higher. But the frequency of entire symptoms mainly appears at acute stage ; the main c

关 键 词：溃疡性结肠炎 症状 临床研究 

分 类 号：R574.62[医药卫生—消化系统]