女性散发性基底细胞型乳腺癌临床病理特征的研究  

Study on the clinicpathologic features of female sporadic basal-like breast cancer

作　　者：毛晓韵[1] 王欢[1] 范垂锋[2] 魏晶[1] 姚凡[1] 刘崇[1] 金锋[1] 

机构地区：[1]中国医科大学附属第一医院肿瘤外科普通外科教研室乳腺外科,辽宁沈阳110001 [2]中国医科大学基础医学院病理学教研室,辽宁沈阳110001

出　　处：《现代肿瘤医学》2012年第3期514-517,共4页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(项目编号:No.30950009)

摘　　要：目的:筛选女性散发性基底细胞型乳腺癌,探讨其临床病理特征。方法:用免疫组化结合荧光原位杂交的方法从500例女性散发性乳腺癌中筛选出基底细胞型乳腺癌,结合形态学及临床病理参数分析散发性基底细胞型乳腺癌的临床病理特征。结果:在500例乳腺癌中共筛出三阴性乳腺癌77例(15.4%),基底细胞型乳腺癌60例(12.0%)。基底细胞型乳腺癌的病理组织学形态学与非基底细胞型乳腺癌并无明显差异。基底细胞型乳腺癌与非基底细胞型乳腺癌相比,其在发病年龄、发病时月经状态及肿瘤TNM分期并无明显统计学差异,二者在肿瘤大小及淋巴结转移上有统计学差异。结论:散发型基底细胞型乳腺癌倾向于原发灶较大,淋巴结转移多。Objective：To screen female sporadic basal-like breast cancer and investigate the clinicopathological characters of basal-like breast cancer.Methods：To screen female sporadic basal-like breast cancer from 500 sporadic breast cancer by immunohistochemistry and fluorescence in situ hybridization and analyze the clinicopathological characters of basal-like breast cancer combined with morphological and clinicopathological factors.Results：Total of 77 cases of triple-negative breast cancer were screened out in 500 sporadic breast caner（77/500,15.4%）,60 cases of sporadic basal-like breast cancer（60/500,12.0%）.There were no significant difference in morphology,age,menopausal status and tumor stage between basal-like breast cancer and non basal-like breast cancer.Statistical analysis revealed a significant difference in tumor size and lymph node metastasis between basal-like breast cancer and non basal-like breast cancer.Conclusion：Sporadic basal-like breast cancer associated with big tumor size and lymph node metastasis.

关 键 词：基底细胞型乳腺癌 免疫组化 荧光原位杂交 临床病理特征 

分 类 号：R737.9[医药卫生—肿瘤]