血清肿瘤标志物联合检测对肺癌的诊断价值  

Diagnostic value of combined detection in serum tumor makers for hung cancer

作　　者：熊杰[1] 白生华[2] 徐万清[1] 古宇[1] 龚杨彬[1] 

机构地区：[1]成都军区总医院检验科,四川成都610083 [2]成都医学院第一附属医院,四川成都610050

出　　处：《现代肿瘤医学》2012年第3期536-538,共3页Journal of Modern Oncology

摘　　要：目的:探讨血清中神经元特异性烯醇化酶(NSE)、细胞角蛋白19片段(CYFRA21-1)和糖类抗原19-9(CA19-9)的水平变化对肺癌的诊断价值。方法:采用化学发光法对125例肺癌患者、80例肺良性疾病患者和80例健康人血清中的NSE、CYFRA21-1和CA19-9含量进行检测及比较。结果:肺癌组的三种血清肿瘤标志物水平均明显高于肺良性疾病患者组和正常对照组,差异均有统计学意义(P<0.05),其中NSE在小细胞肺癌中呈高表达,明显高于鳞癌与腺癌(P<0.01),CYFRA21-1在鳞癌中水平明显高于腺癌与小细胞肺癌(P<0.01),CA19-9在腺癌中水平明显高于其他类型肺癌(P<0.01)。三种肿瘤标志物联合检测阳性率高达84.8%,高于单项检测。结论:三项肿瘤标志物联合检测可提高肺癌诊断的灵敏度和准确度,同时为肺癌病理分型的鉴别诊断提供依据。Objective：To explore the diagnostic value of combined detection in serum NSE,CYFRA21-1 and CA199 levels for lung cancer.Methods：Technique of electrochemiluminescence immunoassay was used to measure the serum NSE,CYFRA21-1 and CA199 levels in 125 patients with lung cancer,80 patients with benign lung diseases and 80 normal controls.Results：The levels of NSE,CYFRA21-1 and CA199 in lung cancer group were significantly higher than those in benign lung diseases and normal control groups（P0.05）.NSE in small cell lung cancer was highly expressed in squamous cell,significantly higher than squamous cell carcinoma and adenocarcinoma（P0.01）;CYFRA21-1 level were significantly higher in squamous cell carcinoma and small cell lung cancer（P0.01）,CA19-9 levels in adenocarcinoma was significantly higher than other types of lung cancer（P0.01）.Three tumor markers positive rate as high as 84.8% in combined detection,higher than the single test.Conchusion：Three tumor markers of combined detection for lung cancer can improve the sensitivity and accuracy,provide the basis for the differential diagnosis in pathological type of lung cancer.

关 键 词：肺癌 NSE CYFRA21-1 CA199 

分 类 号：R734.2[医药卫生—肿瘤]