机构地区:[1]首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室,100730
出 处:《中华眼视光学与视觉科学杂志》2012年第2期109-113,共5页Chinese Journal Of Optometry Ophthalmology And Visual Science
摘 要:目的比较青年近视散光患者在准分子激光原位角膜磨镶术(LASIK)手术前后角膜前、后表面非球面性的分布变化以及可能的影响因素。方法前瞻性系列病例研究。用ALLEGROOculyzer眼前房诊断系统分别在术前和术后1~3个月对北京同仁眼科中心18~39岁的近视散光患者共163例(296眼)进行测量,获得角膜前、后表面20。、25。、30。、35。、40。的Q值(AQ和PQ)及其变化(AAQ和APQ),分析其与屈光参数的关系。对手术前后角膜前、后表面不同范围的Q值进行秩和检验.对术后各Q值与患者屈光度、角膜中央厚度、最大切削深度进行直线相关分析。结果术前角膜各AQ值均与术前柱镜度(CD)呈负相关(r=-.213、-0.279、-0.332、-0.363、-0.133,P〈0.05)。术后各AQ值与术前差异均有统计学意义(皓38.15、43.94、48.47、44.78、25.97,P〈0.05),术后各PQ值与术前差异均有统计学意义(u=9.10、10.18、9.77、7.75、3.30,P〈0.05,)。术后△AQ20、△AQ25、△AQ30、△AQ35、△AQ40与术前球镜度(so)呈正相关(r=0.884、0.870、0.871、0.612、0.370,P〈0.05),与术前等效球镜度(SE)呈正相关(r=0.834、0.866、0.872、0.625、0.388,P〈0.05),与最大切削深度(MD)呈正相关(r=0.779、0.823、0.842、0.634、0.403。P〈0.05).与残留角膜基质厚度(CS)呈负相关(r=-0.332、-0.377、-0.410、-0.352、-0.168,P〈0。05);△AQ35、△AQ40与术前CD呈正相关(r=0.124、O.120,P〈0,05)。△PQ20、△PQ25、△PQ30与术前SD呈负相关(r=-0.210、-0.185、-0.154,P〈0.05),与术前SE呈负相关(r=-0.225、-0.196、-0.169,P〈0.05),与MD呈负相关(r=:-0.210、-0.184、-0.164,P〈0.05)。另外△PQ35与术前SD和SE均呈负相关(r=-0.121、-0.124,P〈0.05),△PQ40与术前SD�Objective To evaluate and compare the distribution of anterior and posterior corneal asphericity in young myopic astigmatism patients before and after laser in situ keratomileusis (LASIK) surgery, and to investigate the possible factors influencing change. Methods This was a prospective case-series study. Patients with myopic astigmatism (18-39 years old) were recruited from Beijing Tongren Eye Center. The Q-values of 20°, 25°, 30°, 35°, 40° of the anterior and posterior corneal surfaces (AQ and PQ) were registered using an ALLEGRO Oculyzer before and after LASIK surgery (1-3 months). Changes in AQ and PQ (△AQ and △PQ) were investigated. Correlations of AQ, PQ, △AQ and △PQ to the refractive index were also analyzed. Data were analyzed with a rank sum test and a Pearson correlation. Results Two hundred ninety-six eyes of 163 patients were studied. The AQ20, AQ25, AQ30, AQ35 and AQ40 of the cornea were -0.24±0.12, -0.28±0.12, -0.31±0.12, -0.35±0.12 and -0.33±0.27 before LASIK surgery, while the PQ20, PQ25, PQ30, PQ35 and PQ40 were 0.21±0.25, 0.04±0.21, -0.10±0.19, -0.20±0.16 and -0.30±0.13. AQ values were negatively correlated with the cylindrical diopter (CD) (r=-0.213, -0.279, -0.332, -0.363, -0.133, P〈0.05). After LASIK surgery both the AQ and PQ values showed significantly changes, which were 0.96±0.55, 0.94±0.48, 0.80±0.40, 0.51±0.35, 0.25±0.36 for the AQs (U=38.15, 43.94, 48.47, 44.78, 25.97, P〈0.05) and 0.31±0.25, 0.14±0.21, -0.02±0.19, -0.16i4).17, -0.29i4).15 for the PQs (U=9.10, 10.18, 9.77, 7.75, 3.30, P〈O.05). △AAQ20, △AQ25, △AQ30, △AQ35 and △AQ4o showed positive correlation with spherical diopter (SD) (r=0.884, 0.870, 0.871, 0.612, 0.370, P〈0.05), spherical equivalent (SE) (r=0.834, 0.866, 0.872, 0.625, 0.388, P〈0.05) and the maximum ablation depth (MD) (r=0.779, 0.823, 0.842, 0.634, 0.403, P〈0.05). They were also negatively correlated with the residual depth of cornea stroma (CS) �
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