细胞间黏附分子1469K／E基因多态性与胃异型增生发病风险的关系  

ICAM-1 469K/E gene polymorphisms increase the risk of gastric dysplasia

作　　者：李忠武[1] 田萌萌[1] 武莹[1] 孙宇[1] 冯国双[2] 游伟程[2] 李吉友[1] 赵爱莲[1] 

机构地区：[1]北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所病理科恶性肿瘤发病机制及转化研究教育部重点实验室,100142 [2]北京大学临床肿瘤学院北京肿瘤医院暨北京市肿瘤防治研究所流行病室,100142

出　　处：《中华肿瘤杂志》2012年第3期192-195,共4页Chinese Journal of Oncology

基　　金：国家高技术研究发展（863）计划（2006AA02A402）;国家重点基础研究发展（973）计划（2004CB518702）

摘　　要：目的研究细胞间黏附分子1（ICAM－1）469K／E基因多态性对慢性萎缩性胃炎和异型增生发病危险性的影响。方法采用多聚酶链式反应扩增产物直接测序方法检测中国北方胃癌高发区山东临朐县一组研究对象（共372例）ICAM－1基因469K／E位点的多态性。存研究计划开始时，所有研究对象的胃镜活检病理均表现为正常或浅表性胃炎，根据5年后的随访结果将研究对象分为非进展组（随访诊断仍为正常或浅表性胃炎，137例）、进展I组（随访诊断为重度萎缩性胃炎，194例）和进展Ⅱ组（随访诊断为低级别异型增生，41例）。结果372例研究对象中，ICAM－1基因469位点KK、KE和EE基因型的分布频率分别为50．5％、39．2％和10．2％。进展I组与非进展组间ICAM－1469K／E基因多态性的差异无统计学意义（P〉0．05）。进展Ⅱ组KK基因型的分布频率（68．3％）硅著高于非进展组（49．6％，P=0．035）和进展I组（47．4％，P=0．015）。携带ICAM－1469KK基因型的个体，其胃黏膜由正常或浅表性胃炎进展为低级别异型增生的危险性显著增加（OR=2．21，95％c，为1．10～4．42）。结论中国北方胃癌高发区人群中ICAM－1469K／E基因多态性明显增加胃黏膜低级别异型增生的发病风险，但与重度萎缩性胃炎的发病无关。Objective To investigate the influence of ICAM-1 469K/E gene polymorphisms on the risk of atrophic gastritis and dysplasia. Methods The ICAM-1 469K/E gene polymorphisms in a total of 372 subjects were detected by polymerase chain reaction-direct sequencing. All of the subjects were from Linqu County, a high risk area of gastric cancer in Shandong Province of northern China. All cases were initially diagnosed as normal or superficial gastritis at the beginning of this study. After a 5-year follow-up, the cases were subdivided into no progression group （ no histological progression, n = 137 ）, progression group I （progressed to severe chronic atrophic gastritis, n = 194） and progression group II （progressed to tow-grade dysplasia, n =41）. Results In all 372 subjects, the frequencies of KK, KE or EE genotype of ICAM-1 Kd69E were 50.5% , 39.2% and 10.2% ,respectively. No significant differences were observed in the ICAM-I 469K/E genotype frequencies between the progression group I and no progression group（ P 〉 0.05 ）. The frequencies of KK genotype （68.3%） were significantly higher in the progression group II than in the no progression group （49.6% ,P =0. 035）, and also than in the progression group I （47.4% ,P= 0.015）. An increased risk of the progressing to dysplasia from normal or superficial gastritis was found in the individuals with ICAM-1 469KK genotype [ odds ratio （OR） =2.21,95% CI, 1.10-4.42]. Conclusion ICAM-1 469K/E gene polymorphisms are significantly associated with the risk of gastric low-grade dysplasia, but not related with severe chronic atrophic gastritis in a population with high risk of gastric cancer in Linqu County, Shandong Province, China.

关 键 词：细胞间黏附分子1 基因多态性 胃异型增生 胃炎 萎缩性 

分 类 号：R735.2[医药卫生—肿瘤]