脑白质疏松轻度认知障碍证候学研究  

Study on Syndrome Factors of Leukoaraiosis Patients with Mild Cognitive Impairment

作　　者：张允岭[1] 郑硕[1] 金香兰[1] 南一楠[1] 郭蓉娟[1] 陈志刚[1] 陈宝鑫[1] 张艳霞[1] 牛焕敏[1] 白文[2] 戴中[2] 赵建军[3] 黎明全[3] 曹晓兰[4] 张玉莲[5] 陈志强[6] 田军彪[6] 

机构地区：[1]北京中医药大学东方医院脑病科,北京100078 [2]北京大学人民医院中医科,北京100044 [3]长春中医药大学第一附属医院脑病科,长春130021 [4]山东中医药大学附属医院老年科,济南250011 [5]天津中医药大学第二附属医院针灸科,天津300150 [6]河北医科大学中医院神经内科,石家庄050000

出　　处：《中国中西医结合杂志》2012年第3期343-347,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：2008年中医药行业科研专项资助(No.200807011);2010年中医药行业科研专项资助(201007002);2011年北京市科技计划项目资助(No.111100056811040);2010年度北京市社区中医药服务科技示范项目资助;北京市新医药科群建设项目(No.XK100270569);北京中医药大学创新团队(No.2011-CXTD-23)

摘　　要：目的探讨脑白质疏松轻度认知障碍(LACI)的主要证候要素,为该病的辨证论治提供依据。方法设计前瞻性观察方案,选取脑白质疏松轻度认知障碍患者103例(LACI组),脑白质疏松无认知障碍患者100例(对照组),观察中医四诊信息,通过因子分析方法,提取证候要素。结果因子分析结果得出LACI组15个公因子(证候要素)、对照组12个公因子,对各例患者证候要素分布情况进行分析,发现LACI组中阳虚占33.98%,痰占22.33%,阴虚占19.42%,气虚占10.68%,火占9.71%,血虚、血瘀占3.88%;对照组中阳虚占31.00%,气虚占27.00%,阴虚、火占24.00%,血虚、血瘀占12.00%,阳虚、痰、血虚占6.00%。结论 LACI的主要证候要素是阳虚、痰、阴虚、火,次要证候要素为气虚、血虚、血瘀。主要涉及肾、脾两脏,次要脏腑为肝、心,以虚为发病基础,痰、火等病理因素为其发展和加重的关键,复合证候要素多,病情复杂。Objective To explore the syndrome factors of leukoaraiosis patients with mild cognitive impairment（LACI） ,thus providing evidence for syndrome typing.Methods The prospective schedule was adopted including 103 LACI patients（as the LACI group） and 100 leukoaraiosis patients without mild cognitive impairment（as the control group） .Syndrome factors were extracted from the patients＇ symptoms with frequency statistics and factor analysis.Results Fifteen common factors were extracted from the LACI group,and 12 common factors from the control group.After analyzed the distribution of syndrome factors in the LACI group,the most common factors were ranked as follows：yang deficiency（33.98%） ,phlegm（22.33%） ,yin deficiency（19.42%） ,qi deficiency（10.68%） ,fire（9.71%） ,blood deficiency and blood stasis（3.88%） .As for the control group,the most common factors were ranked as follows：yang deficiency（31.00%） ,qi deficiency（27.00%） ,yin deficiency and fire（24.00%） ,blood deficiency and blood stasis（12.00%） ,phlegm and yang deficiency and blood deficiency（6.00%） .Conclusions The main syndrome factors of LACI were yang deficiency,phlegm,yin deficiency,and fire.The secondary syndrome factors were qi deficiency,blood deficiency,and blood stasis.It was mainly involved with Shen and Pi,with secondary organs as Gan and Xin.Deficiency syndrome is its pathogenesis.Phlegm and fire,and other pathological factors are essential for its development and aggravation,with more syndrome factors accompanied in complex condition.

关 键 词：脑白质疏松 轻度认知障碍 因子分析 证候要素 

分 类 号：R749.1[医药卫生—神经病学与精神病学]