血清中IL-6、IL-8及TNF-α水平与高血压致急性脑梗死损伤的相关性  

Serum levels of IL-6, IL-8 and TNF-α and acute cerebral infarction by hypertension

作　　者：邰炜彦[1] 王蓓蕾[2] 

机构地区：[1]河北医科大学第三医院心血管一科,石家庄050051 [2]河北医科大学第二医院神经内科,石家庄050000

出　　处：《中华神经医学杂志》2012年第3期269-272,共4页Chinese Journal of Neuromedicine

摘　　要：目的探讨血清中炎性细胞因子与高血压致急性脑梗死（ACI）的相关性。方法选择河北医科大学第三医院心血管一科和神经内科自2007年6月至2009年6月收治的ACI并高血压患者102例（其中小体积梗死30例，中体积梗死45例，大体积梗死27例）和单纯ACI患者30例，同期门诊健康体检正常者30例作为对照组，ELISA检测ACI并高血压组患者入院第1、3、5、7、14天，单纯ACI组、对照组入院第1天血清细胞介素6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子α （TNF-α）水平，分析血清IL-6、IL-8、TNF-α水平与ACI体积的相关性。结果入院第1天ACI并高血压组、单纯ACI组、对照组血清IL-6、IL-8、TNF-α水平均依次降低，差异有统计学意义（P＜0．05）。第1、3、5、7天对照组、小体积梗死组、中体积梗死组、大体积梗死组血清IL-6、IL-8及TNF-α水平依次升高，差异均有统计学意义（P〈0．05）。第14天4组TNF-α水平依次升高，差异有统计学意义（P＜0．05）；ACI并高血压患者血清IL-6、IL-8水平在第1、3、5、7天与ACI体积呈正相关关系，TNF-α水平在在第1、3、5、7、14天与ACI体积呈正相关关系。结论IL-6、IL-8、TNF-α水平与高血压对ACI的发病有协同作用，ACI并高血压患者血清IL-6、IL-8、TNF-α水平与脑梗死的体积相关。Objective To investigate the correlations between serum levels of IL-6, IL-8 and TNF-a and acute cerebral infarction （ACI） caused by hypertension. Methods This study enrolled 102 patients with hypertensive ACI （group A）, 30 patients with simple ACI （group B） and 30 healthy adults （group C） who sought medical intervention or check-up in our hospital between June 2007 and June 2009. Group A was further divided into 3 sub-groups by the infarction volume （30 cases in the small subgroup, 45 cases in the intermediate subgroup and 27 cases in the large subgroup）. The serum levels of IL-6, IL-8 and TNF-ain groups A, B and C were measured on 1, 3, 5, 7, 14 days post-admission and compared. The correlation of the serum levels of IL-6, IL-8 and TNF-a with the infarction volumes in group A was analyzed. Results The serum levels of IL-6, IL-8 and TNF-a decreased significantly on the first day post-admission from group A to group C （P〈0.05）. The serum levels of IL-6, IL-8 and TNF-a significantly increased, in turn, from group C, the small subgroup, the intermediate subgroup to the large subgroup on 1, 3, 5, 7, 14 days post-admission except for the levels of IL-6 and IL-8 on 14 days post-admission （P〈0.05）. In group A, the serum levels of IL-6 and IL-8 were positively correlated with the infarction volume on 1, 3, 5, 7 days post-admission while the serum level of TNF-a was positively correlated with the infarction volume on 1, 3, 5, 7, 14 days post-admission. Conclusions IL-6, IL-8, TNF-a and hypertension play a joint role in cerebral infarction. Serum levels ofIL-6, IL-8 and TNF-a are closely related to the volume of cerebral infarction in ACI patients.

关 键 词：白细胞介素-6 白细胞介素-8 肿瘤坏死因子Α 急性脑梗死 相关性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]