p53、PTEN和VEGF在胃癌组织中的表达及意义  

Expression and significance of p53,PTEN,VEGF in gastric cancer tissue

作　　者：孙晓春[1] 孙镇江[1,2] 吴乐乐[1] 谢岩[1] 朱伟[1] 

机构地区：[1]江苏大学基础医学与医学技术学院,江苏镇江212013 [2]常州第二人民医院

出　　处：《山东医药》2012年第7期18-20,共3页Shandong Medical Journal

基　　金：江苏省自然科学基金资助项目(BK2008232)

摘　　要：目的探讨p53、PTEN、VEGF表达在胃癌发生、发展中的作用及其相关影响因素。方法采用免疫组织化学法检测80份胃癌组织中p53、PTEN、VEGF表达,并分析其与胃癌临床病理特征的关系。结果 p53、PTEN、VEGF在胃癌组织中的阳性表达率依次为55%(44/80)、92.5%(74/80)、52.5%(42/80);胃癌组织中p53、VEGF表达阳性率明显高于对照组,P<0.01。三者表达与性别、年龄、肿瘤分化程度、浸润情况、淋巴结转移等均无明显相关性;任意两个指标之间相关性亦不显著。结论 p53、VEGF对胃癌的诊断有一定价值;p53、VEGF、PTEN对胃癌肿瘤分化、浸润和转移等的诊断价值不大,各指标间的相关性不显著。Objective To investigate the roles of p53,phosphatase and tensin homolog deleted on chromosometen（PTEN） and vascular endothelial growth factor（VEGF） expression in the occurrence and development of gastric cancer,and to analyse their related factors.Methods The expression of p53,PTEN and VEGF protein were detected by immunohistochemical method in 80 patients with gastric carcer,and their corresponding clinical data were analysed retrospectively.Results The positive expression rates of p53,PTEN and VEGF protein in gastric cancer tissue were 44/ 80（55%）,74/80（92.5%）,42/80（52.5%）.The positive expression rates of p53,VEGF were higher than those in healthy controls（P0.05）.The positive expression rates of p53,PTEN and VEGF protein were not closely relevant to the gender,age,differentiation,invasion and metastasis;no significant correlations were found between any two indexes.Conclusion p53 and VEGF play important roles in gastric cancer diagnosis,but p53,VEGF and PTEN play small roles in cancer differentiation,invasion and metastasis,and there are no closely correlations among the three indexes.

关 键 词：P53 人第10号染色体缺失的磷酸酶及张力蛋白同源基因 血管内皮生长因子 胃肿瘤 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]