胃肠间质瘤的诊断与治疗分析  

Diagnosis and treatment of gastrointestinal stromal tumor

作　　者：王海涛[1] 卞栋[1] 李成华[1] 王矛[1] 庄严[1] 

机构地区：[1]安徽省蚌埠市第三人民医院普外科,233000

出　　处：《淮海医药》2012年第2期110-112,共3页Journal of Huaihai Medicine

摘　　要：目的探讨胃肠道间质瘤(GIST)的诊断及治疗方法。方法回顾性分析经手术后病理证实的GIST 16例临床资料。结果肿瘤位于胃部10例,小肠5例,直肠1例。其中12例达到外科根治性切除。2例因肿瘤广泛转移行姑息切除。2例伴肝转移者中1例行原发灶及转移灶切除,1例不能切除的肝转移灶,术后辅以药物治疗。术后平均随访22个月,12例中术后复发转移3例,复发间期平均14个月,其中2例再次手术治疗,其他1例带瘤生存12个月。结论外科手术切除原发灶及肝转移灶是治疗GIST的首选有效方法,不易切除的肝转移灶,术后应辅以药物治疗。GIST远期仍存在较高的复发转移率。对复发转移病例,仍应争取再手术治疗。Objective To investigate diagnosis and treatment methods of gastrointestinal stromal tumors（GIST）.Methods 16 clinical cases with pathologically proved GIST at our hospital from January 2002 to December 2010 were retrospectively analyzed.Results The tumors originated respectively from the stomach（n=10）,the intestine（n=5）,and the rectum（n=1）.12 cases received curative resection.Two cases underwent palliative resection because of extensive metastasis.Among the 2 cases of hepatic metastases,one case underwent primary tumor and hepatic metastases resection,and the other could not and was followed by medicine treatment after operation.Postoperative recurrence or metastasis of GIST was found in 3 cases during an average follow-up of 22 months,with the average latency of 14 months.Two recurrent cases received reoperation,and the other case survived 12 months.Conclusion Complete resection of primary tumors and metastatic lesions are the effective treatment for GIST.If the hepatic metastases were not resected,medicine should be followed after operation.GIST patients can survive with recurrent tumors for a comparatively long time.Reoperation may prolong the survival of patients with GIST who suffer from postoperative recurrence.

关 键 词：胃肠道间质肿瘤 外科手术 肿瘤转移 

分 类 号：R735.2[医药卫生—肿瘤]