高压氧联合依达拉奉治疗外伤性脑梗死150例临床观察  

Clinical observation on 150 cases of traumatic cerebral infarction treated by edaravone combined with hyperbaric oxygen

作　　者：王勇[1] 李心国[1] 姚长义[1] 王运杰[1] 

机构地区：[1]中国医科大学附属第一医院,110001

出　　处：《山西医药杂志（上半月）》2012年第3期213-214,共2页Shanxi Medical Journal

基　　金：国家自然科学基金(81000565/H0914)

摘　　要：目的观察高压氧联合依达拉奉治疗外伤性脑梗死的临床疗效。方法 150例外伤性脑梗死患者随机分为治疗Ⅰ组(常规治疗加用依达拉奉)、治疗Ⅱ组(常规治疗加用依达拉奉并联合高压氧)、对照组(常规治疗)各50例,对治疗前后神经功能缺损平均积分及治疗有效率进行组间比较。结果治疗Ⅰ组与治疗Ⅱ组上述指标明显优于对照组,且治疗Ⅱ组疗效更佳(P<0.01)。结论依达拉奉能有效改善外伤性脑梗死患者的临床预后,结合高压氧治疗会进一步提高疗效。Objective To evaluate the clinical effects of edaravone combined with hyperbaric oxygen on patients with tramatic cerebral infarction. Methods One hundred and fifty cases of traumatic cerebral infarction patients were randomly divided into treatment group I （edaravone,n= 50）, treatment group 11 （edaravone combined with hyperbaric oxygen,n= 50） and control group （n= 50）. Neurologic impairment score and rate of effect were compared between 3 groups. Results Basic recovery rate and total effective rate of treatment were significantly higher （P〈0. 01） than control group. Neurologic impairment score of treatment groups significantly decreased （P〈0. 01） than pretherapy. Conclusion Edaravone can effectively improve the clinical prognosis of patients with traumatic cerebral infarction, and hyperbaric oxygen can improve the therapeutic effect.

关 键 词：高压氧 脑梗塞 依达拉奉 

分 类 号：R743.3[医药卫生—神经病学与精神病学]