天然植物提取物对六价铬所致染色体损伤的拮抗作用研究  

Study on Antagonism of Natural Plants Extracts on Chromosomal Damages Induced by Chromium(Ⅵ)

作　　者：徐厚铨[1] 郭冬梅 韩发彬[1] 赵拥军[2] 

机构地区：[1]山东医科大学环境卫生教研室,济南250012 [2]滨州医学院卫生学教研室

出　　处：《环境与健康杂志》2000年第2期100-102,共3页Journal of Environment and Health

摘　　要：[目的 ]研究枸杞、仙人掌和海藻 3种天然植物提取物拮抗六价铬对染色体损伤作用。 [方法 ]小鼠骨髓嗜染红细胞 (PCE)微核试验和人外周血淋巴细胞染色体畸变试验。 [结果 ] 3种提取物均抑制小鼠骨髓细胞微核率及人外周血淋巴细胞畸形率及其染色体畸形率。 [结论 ]枸杞、仙人掌和海藻提取物对六价铬的染色体损伤有显著的抑制作用 ,同时表现出Objective]To study the antagonism of natural plant extracts,such as marine alga,fruit of Chinese wolfberry and cactus,on chromosomal damages induced by chromium(Ⅵ) [Methods]Micronucleus test in mouse bone marrow cells and chromosomal aberration test in human peripheral blood lymphocytes [Results]3 kinds of plant extracts revealed significant inhibitions on the micronucleus rates of bone marrow cells in mice,the rates of aberrant cells and chromosomes of human peripheral blood lymphocyes respectively.[Conclusion]The extracts of observed 3 kinds of plants could significantly antagonized the chromosomal damages induced by chromium(Ⅵ) respectively,and this antagonistic actions revealed significant differences between 3 kinds of plants extrats

关 键 词：抗诱变剂 植物 六价铬 染色体畸变 拮抗作用 

分 类 号：R994.6[医药卫生—毒理学] R282.71[医药卫生—药学]