缺氧诱导因子-1α在宫颈癌中的表达及其与临床病理因素的关系  

Expression of HIF-1α and Its Correlation with Clinicopathological Factors in Cervical Carcinoma

作　　者：王丽华[1] 李胜泽[1] 王亮[1] 王蓓蓓[1] 

机构地区：[1]蚌埠医学院第一附院妇瘤科,安徽蚌埠233004

出　　处：《解剖与临床》2012年第1期29-32,共4页Anatomy and Clinics

摘　　要：目的：探讨在宫颈癌中缺氧诱导因子-1α（HIF-1α）的表达及其与临床病理因素的关系。方法：应用免疫组织化学S-P方法检测77例宫颈癌（ICC）组织中HIF-1α的表达情况；分析HIF-1α阳性表达水平与是否有淋巴结转移、脉管浸润及肿瘤大小、临床分期等临床病例因素间的关联性。结果：HIF．1et蛋白在宫颈癌中表达阳性率为70．1％（54／77），在宫颈鳞癌中表达阳性率是77．4％（48／62），腺癌中阳性表达率为40．0％（6／15），差异有统计学意义（P〈0．05）；HIF-1α蛋白表达与淋巴结转移，脉管浸润及肿瘤大小等无关（P〉0．05），而与临床期别、细胞分化程度及间质浸润有关（P〈0．05）。结论：HIF-1α表达水平与肿瘤细胞的去分化程度及间质浸润正相关。宫颈癌中HIF-1α蛋白可能通过对靶基因的调控提高了肿瘤细胞恶性潜能，促进了宫颈癌的浸润转移。Objective：To examine the expression of HIF-1α and its correlation with clinicopathological factors in cervical carcinoma. Methods：Immnnohistochemistry S -P method was used to detect the expression of HIF-1α in 77 cases with early invasive carcinoma of cervix （ICC）, and analyze relevance of the degree of HIF-1α expression with clinicopathological factors in cervical carcinoma, such as lymph node metastasis, intra- vascular involvement, tumor size, tumor stage. Results：The positive rate of HIF-1α protein was 77.4% （48/62） in cervical spuamous cell carcinoma（SCC） and 40.0% （6/15） in cervical adenocarcinoma（ AC）, there was significant difference （P 〈0.05 ）. In addition, the degree of HIF-la expression was significantly higher in SCCs than that of ACs （P 〈 O. 05 ）. Expression of HIF-1α was not related with lymph node metastasis, intravascular involvement and tumor size （ P 〉 0.05 ）, but related with tumor stage , cell differentiation and stroma infiltration. Conclnsions：Expression of HIF-1α has a positive correlation with cell differentiation and stroma infiltration. HIF-1α protein may enhance malignant potency of tumor cell by regulating the expression of target gene by transcriptional activation, and promote the infiltration of cervical carcinoma.

关 键 词：宫颈癌 缺氧诱导因子 免疫组织化学法 

分 类 号：R737.33[医药卫生—肿瘤] R446.63[医药卫生—临床医学]