胃癌中肿瘤微环境转移的价值  

The value of tumor microenvironment of metastasis in gastric cancer

作　　者：齐蕾[1] 单丽辉[1] 柴翠翠[1] 周秋锋[1] 姚珂[1] 顾云鹤[1] 周敏[1] 韩伟[1] 王立峰[1] 

机构地区：[1]哈尔滨医科大学附属第一临床医院病理科,哈尔滨150001

出　　处：《临床与实验病理学杂志》2012年第3期274-277,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：黑龙江省自然科学基金(D201103);黑龙江省教育厅科学技术研究项目(12511191)

摘　　要：目的研究胃癌中是否存在肿瘤微环境转移(tumor microenvironment of metastasis,TMEM)及其与胃癌血道转移的相关性。方法采用免疫组化双染法同时标记巨噬细胞和内皮细胞,计数26例远处转移及其配对26例无远处转移胃癌组织中TMEM密度。结果 (1)TMEM存在于胃癌组织中;(2)TMEM与分化程度、临床分期明显相关(P<0.001,P=0.006),与肿瘤大小、Lauren分型、淋巴结转移等其他临床病理特点无关(P均>0.05);(3)TMEM与有无远处转移呈正相关(P<0.001)。结论证实胃癌中存在TMEM,TMEM密度可以预测胃癌血道转移,有望成为评估胃癌血道转移危险性的新预测指标。Purpose To investigate whether or not present tumor microenvironment of metastasis（TMEM） in gastric cancer and its relationship with hematogenous metastases.Methods A case-control study of 26 patients who developed metastatic gastric cancer and 26 patients without metastatic disease was done.Paraffin-embedded gastric cancer samples were stained using double-immunostaining method allowing simultaneous identification of macrophages and endothelial cells.Then TMEM density was evaluated.Results（1）TMEM was present in gastric cancer.（2）TMEM density was related to cancer differentiation and clinical stages（P0.001,P=0.006）,but had no relationship with other characteristics of pathology,such as the tumor size,Lauren classification and lymph node metastasis（P0.05）.（3）TMEM density had a positive correlation with distant metastasis（P0.001）.Conclusions They demonstrate that TMEM is present in gastric cancer.TMEM density can predict the development of hematogenous metastases and may be a useful new prognostic marker for gastric cancer patients.

关 键 词：胃肿瘤 肿瘤相关巨噬细胞 微血管密度 肿瘤微环境转移 血道转移 

分 类 号：R735.2[医药卫生—肿瘤]