工业微生物菌种改造的新方法——优势小基因组生产菌的构建  

New method for industrial microbial strains improvement——construction of dominant genome-simplified strains—A review

作　　者：王媛媛[1] 郭文斌[1] 宋存江[1] 

机构地区：[1]南开大学分子微生物学与技术教育部重点实验室,天津300071

出　　处：《微生物学报》2012年第3期286-294,共9页Acta Microbiologica Sinica

基　　金：国家"973项目"--国家重点基础研究发展计划(2012CB725204);国家自然科学基金(31070039;31170030;51073081)~~

摘　　要：本文介绍了构建优势小基因组生产菌株的必要性和可行性;介绍了优势小基因组工业微生物的构建原理和方法;同时,还介绍了几个目前已成功应用的通过基因组精简提高生产效率的例证;最后,结合作者的研究对优势小基因组生产菌的应用进行了展望。The necessity and feasibility of constructing dominant genome-simplified strains for industrial production were introduced,based on some successful cases in which the production efficiency was improved after simplifying the genome of strains.The principle and process of genome simplifying were summarized.In addition,the perspective of dominant genome-simplified strains for industrial production was discussed,combined with authors＇ own studies.

关 键 词：菌种改造 必需基因 基因组精简 

分 类 号：TQ920.1[轻工技术与工程—发酵工程]