胰腺浆液性微囊性腺瘤临床病理分析  

Serous microcystic adenoma of pancreas： a clinicopathological study

作　　者：陈波[1] 倪型灏[1] 蒋友华[2] 程国平[1] 邝平定[3] 陈俊英[4] 

机构地区：[1]浙江省肿瘤医院病理科,杭州310022 [2]浙江省肿瘤医院外科,杭州310022 [3]浙江省肿瘤医院放射科,杭州310022 [4]浙江省肿瘤医院超声科,杭州310022

出　　处：《中华肝胆外科杂志》2012年第3期176-179,共4页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的探讨胰腺浆液性微囊性腺瘤的临床病理特征及其诊断与鉴别诊断。方法对7例胰腺浆液性微囊性腺瘤病例的临床资料、病理形态、免疫组化进行分析。结果7例患者均为女性，平均年龄51岁，有临床症状者2例（28．6％）。镜下肿瘤主要由大小不等的囊腔组成，囊壁衬覆单层立方上皮，细胞胞质透明并富含糖原。上皮细胞核小而圆，居中，无核仁，无核分裂象。部分囊腔之间可见粗大的纤维组织分隔。免疫组化上皮细胞AEl／AE3、CK7、CK8、CKl9、CK／LMW、EMA（＋）；CEA、CD31、CD34、D2—40、Syn、CgA、Calretinin、Vim（-）。结论胰腺浆液性微囊性腺瘤是一种较为少见的良性肿瘤，老年女性好发，预后好，确诊主要靠术后病理组织学和免疫组化。Objective To study the clinicopathological features in the diagnosis of serous micro- cystic adenoma of pancreas. Method A clinicopathological and immunohistochemical study was con ducted on 7 patients with serous microcystic adenoma of pancreas. Results All the patients were female, with a mean age of 51 years. Clinical symptoms were present in 2 （28.6%） patients. On microscopy, the tumor composed of variable-sized cysts. The cyst wall was covered by simple cuboidal epithelium. The cytoplasm was clear and glycogen-rich. The nucleus of the epithelial cells was small and round. In the center, there was no nucleolus and no nuclear division. There were bulky fibrous tissues between the cystic cavities. Immunohistochemical study showed AE1/AE3, CK7, CKS, CK19, CK/LMW, EMA were positive, and CEA, CD31, CD34, D2-40, Syn, CgA, Calretinin, Vim were negative. Conclusions Serous microcystic adenoma of pancreas is a rare tumor, which was common in old women. Serous microcystic adenoma of pancreas is a benign tumor with good prognosis. The diagnosis is made on histopathological and immunohistochemical study.

关 键 词：胰腺 浆液性微囊性腺瘤 临床病理分析 

分 类 号：R735.9[医药卫生—肿瘤]