SDF-1和CXCR4在鼻内翻性乳头状瘤的表达及意义  

The expression and sense of the SDF-1 and the CXCR4 in Nasal inverted papilloma

作　　者：王世军[1] 张爱华[1] 范宗宪[1] 魏晓丽[1] 李江华[1] 

机构地区：[1]黑龙江省佳木斯大学附属第一医院耳鼻喉科,黑龙江佳木斯154002

出　　处：《中国现代医学杂志》2012年第6期40-43,共4页China Journal of Modern Medicine

基　　金：佳木斯大学科研项目(No:S2010-82)

摘　　要：目的探讨基质细胞衍生因子-1(SDF-1)和趋化因子受体4(CXCR4)在鼻内翻性乳头状瘤(NIP)中的表达及其在该病发生、发展中的意义。方法采用免疫组织化学方法检测41例鼻内翻性乳头状瘤、38例正常鼻腔黏膜(NM)、17例鼻鳞状细胞癌(NSCC)组织中SDF-1和CXCR4的表达。结果 SDF-1和CXCR4在NM、NIP、NSCC中的表达呈递增趋势,两两对比,其差异均有显著性(P<0.05)。SDF-1和CXCR4在NIP中的表达呈显著正相关(P<0.01)。结论 SDF-1和CXCR4均参与NIP的发生、发展过程,并且二者之间存在反馈调节机制,在NIP的发生、发展过程中起协同作用。[Objective] To research the expression of the Stromal cell-derived factor-1 （SDF-1） and Cys-X-Cys receptor-4 （CXCR4） in Nasal inverted papilloma （NIP） and their effect in the occurrence and development of NIP. [Methods] Detected the expression of SDF-1 and CXCR4 in tissue samples of 41 cases of NIP, 38 cases of normal nasal cavity mucosae （NM） and 17 cases of nasal prickle cell carcinoma （NSCC） using immunohistochemistry meth- ods. [Results] The expression of SDF-1 and CXCR4 in NM, NIP and NSCC had an increasing tendency and their differences were exceeding significant （P 〈0.05） contrasting each others.The expression of SDF-1 and CXCR4 in NIP was notable positively correlated（P 〈0.01）. [ Conclusion] The result suggested that the SDF-1 and CXCR4 both par- ticipated in genesia and growth of the NIP, there being a feedback regulation mechanism in them and they both jointly contributed to the formation of the NIP.

关 键 词：鼻内翻性乳头状瘤 基质细胞衍生因子-1 趋化因子受体4 免疫组织化学 

分 类 号：R739.62[医药卫生—肿瘤]