血糖控制对高血糖危象患者血单核细胞趋化蛋白MCP-1活性的影响  

The effects of blood glucose control on levels of monocyte chemoattractant protein-1(MCP-1)activity in peripheral blood of patients with hyperglycemic crisis

作　　者：何泉[1] 罗海明[1] 唐新华[1] 朱宝生[1] 陈安宝[2] 陈嘉勇[2] 

机构地区：[1]云南省第一人民医院急诊科,昆明650032 [2]昆明医学院附属第二医院

出　　处：《中国糖尿病杂志》2012年第3期216-218,共3页Chinese Journal of Diabetes

摘　　要：目的探讨血糖控制对高血糖危象患者外周血单核细胞趋化蛋白-1(MCP-1)水平的影响。方法选取DKA和非酮症高血糖高渗(NKH)患者84例检测其治疗前后外周血单核细胞趋化蛋白MCP-1水平变化,以56名健康体检者作对照。结果在血糖控制达标后,高血糖危象组治疗前MCP-1水平显著高于健康对照组(P<0.05);高血糖危象组治疗前后外周血单核细胞趋化蛋白MCP-1水平差异有显著的统计学意义(P<0.05)。相关分析显示外周血单核细胞趋化蛋白MCP-1水平与FBG、2hBG、HOMA-IR呈正相关(r=0.506,r=0.854,r=0.283,P<0.01)。结论血糖控制后外周血单核细胞趋化蛋白MCP-1水平明显下降,血糖下降带来炎症状态的改变。Objective To investigate the effects of blood glucose control on levels of monocyte cbemoattractant protein-1 （MCP-1）activity in peripheral blood of patients with hyperglycemic crisis. Methods A total of 84 patients with diabetic ketoacidosis （DKA）and nonketotic hyperglycemia （NKH） patients were selected. MCP-1 levels were assayed at 72 hours after glucose control. Serum MCP-1 was assayed by ELISA. Results The serum MCP-1 before treatment were higher in patients with hyperglycemia crisis than in normal control. The relationship analysis showed that MCP-1 levels were positivily related to fasting blood glucose （FBG）, 2-h postprandial glucose,and HOMA-IR（r=0. 506,r=0. 854,r=0. 283,P〈0. 01）. Conclusion The levels of serum MCP-1 are decreased at 72 hours after blood glucose control. The improvement of blood glucose control contributes to the improvement of inflammatory status.

关 键 词：高血糖危象 炎症 MCP-1 糖尿病 2型 

分 类 号：R587.1[医药卫生—内分泌]