二次聚焦超声辐射对小鼠宫颈癌U14肿瘤复发和转移的影响  

The effects of repeated irradiation with focused ultrasound on recurrent and metastasized murine cervical carcinoma

作　　者：熊希[1] 彭斌[2] 林川[1] 郭宇[1] 翟蓓[1] 张家模[3] 李成志[1] 

机构地区：[1]重庆医科大学生物医学工程学院超声工程研究所 重庆市超声医学工程重点实验室,重庆400016 [2]重庆医科大学公共卫生学院卫生统计教研室,重庆400016 [3]重庆医科大学附属永川医院泌尿外科

出　　处：《中华物理医学与康复杂志》2012年第3期190-192,共3页Chinese Journal of Physical Medicine and Rehabilitation

基　　金：基金项目：国家重点基础研究发展计划（973计划）（2011CB707906）

摘　　要：目的观察二次聚焦超声辐射对小鼠腿部移植的宫颈癌U14肿瘤复发和转移的影响。方法将72只腿部移植成功的U14宫颈癌小鼠按随机数字表法随机分为一次辐射组、二次辐射组和手术切除组，每组小鼠24只。一次辐射组于移植肿瘤后第7天接受1次聚焦超声辐射治疗；二次辐射组于移植肿瘤后第7天接受1次聚焦超声辐射治疗，第8天接受第2次聚焦超声辐射治疗；手术切除组于移植肿瘤后第7天切除原发肿瘤。3组小鼠均于肿瘤移植后第23天检测其抑瘤率和抑制转移率。结果二次辐射组的抑瘤率和抑制转移率分别为61．70％和68．18％，显著高于一次辐射组的41．84％和31．82％，差异有统计学意义（P〈0．05）。结论一次聚焦超声辐射和二次聚焦超声辐射对肿瘤的局部复发和转移均有明显的抑制作用，且二次聚焦超声辐射较一次聚焦超声辐射的治疗作用更强。Objective To investigate the efficacy of twice irradiating with focused ultrasound on recurrent and metastasized U14 cervical cancer implanted in the legs of mice. Methods Seventy-two mice with U14 cervical cancer cells implanted in their legs were divided into three groups randomly, with 24 rats in each group. One group received a single dose of focused ultrasound, while mice in the second group were irradiated twice and surgery resection was administered to the third group 7 or 8 days after the tumor was implanted. After 23 days post implantation of the tumor, local tumor recurrence and metastasis to the lungs and lymph nodes were evaluated. Results The inhibition rate after double irradiation was 61.70% for local recurrence and 68. 18% for metastasis, significantly higher than in the other two groups. Conclusions Both single and double irradiation with focused ultrasound are effective for inhibiting local recurrence and metastasis, but double irradiation is more effective.

关 键 词：聚焦超声 小鼠 子宫肿瘤 复发 肿瘤转移 

分 类 号：R737.33[医药卫生—肿瘤]