MTNR1B基因多态性与宁夏汉族2型糖尿病患者脂质谱的关系  

The correlation of MTNR1B gene polymorphism with type 2 diabetes mellitus in Ningxia Han population

作　　者：刘英[1] 周林[1] 谢晓敏[2] 杨泽[3] 

机构地区：[1]宁夏医科大学,宁夏银川750001 [2]宁夏医科大学第二附属医院 [3]卫生部北京老年医学研究所

出　　处：《中国老年学杂志》2012年第6期1119-1121,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金资助(No.81061120527);宁夏自然科学基金资助(NZ08145)

摘　　要：目的探讨MTNR1B基因多态性与宁夏汉族2型糖尿病患者体内脂质谱的关系。方法依据病例-对照设计方法,采用全自动生化分析仪等技术检测2型糖尿病患者体内脂质谱;应用PCR-RFLP法对宁夏汉族2型糖尿病患者295例、正常对照239例的MTNR1B rs1387153基因多态性进行分析。结果两组人群的MTNR1B rs1387153 C/T位点基因型和等位基因频率比较差异无统计学意义(P>0.05)。三种基因型的TG比较差异有统计学意义(P=0.046),T型等位基因的TG水平高于C等位基因。Logistic回归分析显示与2型糖尿病密切相关的独立危险因素依次是TG(P=0.001)和腰围(P=0.027)。结论 MTNR1B rs138715基因多态性与宁夏地区汉族2型糖尿病不具有相关性,但与TG水平相关。Objective To study the relationship between gene polymorphism of MTNR1B and type 2 diabetes mellitus（T2DM）,particularly with the lipid spectrum of T2DM in Ningxia Han population.Methods An automatic biochemical analyzer was used to determine the lipid spectrum of T2DM according to case-control design methods.The analysis samples include 295 patients of Han people in Ningxia regions were determined by PCR-RFLP and 239 genetic diversity of MTNR1B rs1387153 determined normally.Results There were no significant differences of genotype and allele frequency between the two groups in MTNR1B rs1387153 C/T（P0.05）,there was significant difference in genotype TG between three groups and the level of TG of allele T was higher than that of allele C.Logistic regression analysis showed T2DM was closely related to TG（P=0.001） and waist（P=0.027）.Conclusions Genetic diversity of MTNR1B rs1387153 is related with T2DM in Han people in Ningxia regions and is also related with the concentration of TG.

关 键 词：MTNR1B基因 2型糖尿病 基因多态性 甘油三酯(TG) 宁夏汉族 

分 类 号：R587.1[医药卫生—内分泌]