银杏叶片联合尼莫地平在短暂性脑缺血发作中的应用  

Application of Ginkgo biloba combined nimodipine in transient ischemic attack

作　　者：张彩霞[1] 

机构地区：[1]新乡市中心医院神经内一科,河南新乡453000

出　　处：《现代预防医学》2012年第6期1565-1566,1569,共3页Modern Preventive Medicine

摘　　要：目的探讨银杏叶片联合尼莫地平在治疗短暂性脑缺血发作中的应用价值及临床疗效。方法选择2010年3月～2011年2月期间在我院诊断为短暂性脑缺血发作患者共62例,随机分为观察组及对照组各31例,对照组患者给予肠溶阿司匹林及尼莫地平治疗,观察组在对照组用药的基础上联合使用银杏叶片口服。观察两组患者在用药前后血浆粘度、红细胞比容、血小板聚集率、全血黏度、纤维蛋白原的变化,治疗后短暂性脑缺血发生变化情况。结果两组患者血液流变学指标治疗后比治疗前明显改善,差异有统计学意义(P﹤0.05);两组治疗后检测结果比较,观察组患者比对照组患者下降更为明显,两组之间差异有统计学意义(P﹤0.05);观察组患者治愈率及有效率高于对照组,但差异无统计学意义(P﹥0.05),总有效率比较差异有统计学意义(P﹤0.05)。结论银杏叶片联合尼莫地平治疗短暂性脑缺血发作,可以有效改善患者血液流变学指标,治疗及预防短暂性脑缺血发作效果明显。OBJECTIVE To investigate the value and clinical efficacy of the effect of GBE combined nimodipine in the treat- ment of transient ischemic. METHODS 62 patients which diagnosed in our hospital during the transient isehemie attack from March 2010 to February 2011 were chose, and were randomly divided into two groups, 31 patients in control group were treat- ed with aspirin and nimodipine treatment, medication group were observed based on the joint use of oral Ginkgo biloba. The change in plasma viscosity, hematocrit, platelet aggregation, blood viscosity, fibrinogen changes before and after treatment and transient ischemic changes were observed. RESULTS There were significantly improved in hemorheology after treatment than that before treatment, there was a significant difference （P 〈 0.05） ; The test results after treatment patients were alore pronounced decline compared to the observation group than in the control group, In the two groups, there was significant differ- ence （P 〈 0.05） ; the cure rate and efficiency of the observation group were higher, but no significant difference was found （P 〉 0.05）. There was significant difference in the total effective rates of the two groups （P 〈 0.05 ）. CONCLUSION Ginkgo com- bined nimodipine in treatment of transient ischemie attack, can improve the blood rheoloKy of patients, treatment and preven- tion of transient ischemic attack significantly.

关 键 词：短暂性脑缺血发作 银杏叶片 尼莫地平 血液流变学 

分 类 号：R743.31[医药卫生—神经病学与精神病学]