地中海贫血孕妇的妊娠状况及对妊娠结局的影响  

Analysis on pregnancy condition of the pregnant women with thalassemia and the impact on pregnancy outcome

作　　者：梁莉[1] 

机构地区：[1]广西百色市妇幼保健院优生遗传室,533000

出　　处：《中国妇幼保健》2012年第9期1380-1382,共3页Maternal and Child Health Care of China

摘　　要：目的:探讨住院分娩的孕妇地中海贫血的妊娠发病情况,以及对妊娠结局的影响。方法:收集该院自2008年5月～2010年5月进行系统产前检查并住院分娩的孕妇资料共计114例,其中正常对照组孕妇48例,非地中海贫血组(非地贫组)34例,地中海贫血组(地贫组)32例,回顾性分析地中海妊娠孕妇的妊娠状况及妊娠结局的差异。结果:地贫组孕妇的红细胞平均体积(MCV)及红细胞平均血红蛋白含量(MCH)的值与正常对照组和非地贫组比较,差异具有统计学意义(P<0.05);地贫组与非地贫组孕妇的异常妊娠发生率与正常对照组比较显著升高,差异具有统计学意义(P<0.05);地贫组和非地贫组的异常妊娠发生率、剖宫产率、早产率明显高于正常对照组(P<0.05);3组间新生儿体重的平均值比较无统计学差异(P>0.05)。结论:对孕妇做血常规检查,其MCV、MCH值可以作为妊娠合并地中海贫血临床检测的指征,若孕妇为地中海贫血患者,要做好对妊娠足月分娩孕妇的健康护理工作,避免胎儿宫内生长发育过程中的不利影响,对地贫及非地贫的孕妇要加强产前的检查工作。To explore the pregnancy condition of the hospitalized pregnant women with thalassemia and the impact on pregnancy outcome. Methods： The data of 114 pregnant women who received systematical prenatal examination and gave birth in the hospital from May 2008 to May 2010 were collected, including 48 pregnant women in normal control group, 34 pregnant women in nonthalassemia group, and 32 pregnant women in thalassemia group. The pregnancy condition and the difference of pregnancy outcome of the pregnant women with thalasscmia were analyzed retrospectively. Results： There was significant difference in mean corpuscular volume （MCV） and mean corpuscular hemoglobin （MCH） values between thalassemia group and normal control group, nonthalassemia group （P 〈 0. 05 ） ; the incidences of abnormal pregnancy in thalassemia group and nonthalassemia group were significantly higher than that in normal control group （P 〈 0.05） ; the incidences of abnormal pregnancy, the rates of cesarean section, and the incidences of premature delivery in thalassemia group and nonthalassemia group were significantly higher than those in normal control group （P 〈 O. 05 ） ; there was no significant differ- ence in the mean body weight of neonates among the three groups （P 〉 0.05 ） . Conclusion： The pregnant women should receive routine blood test, their MCV and MCH values can be used as indexes for clinical detection of pregnancy combined with thalassemia; for the pregnant women with thalassemia, the health nursing should be enhanced for fullterm pregnant women, and the adverse effects in the course of fetal intrauterine growth and development should be avoided, prenatal examination should be strengthened among the pregnant women with or without thalassemia.

关 键 词：地中海贫血 妊娠 妊娠结局 临床分析 

分 类 号：R714[医药卫生—妇产科学]