箬叶多糖对宫颈癌的抑制及免疫功能的影响  

Impact of indocalamus tesselatus polysaccharides on cervical cancer and immunity

作　　者：靳祎[1] 王恩军[1] 宋洁[1] 关宏[2] 刘斌[3] 

机构地区：[1]河北大学医学部基础医学院,保定071000 [2]河北省保定市第一中心医院 [3]河北省保定市急救中心

出　　处：《中国计划生育学杂志》2012年第3期164-167,共4页Chinese Journal of Family Planning

基　　金：河北省人口和计划生育委员会科研计划项目(2009-B18;2010-A06);河北省中医药管理局科研计划项目(2009061);保定市科技局科学技术研究与发展指导计划项目(09ZF004;09ZF011)

摘　　要：目的:探讨箬叶多糖对荷瘤小鼠的抗肿瘤作用及免疫学功能的影响。方法:采用小鼠宫颈癌U14细胞移植瘤模型,观察3个剂量箬叶多糖的体内抗肿瘤作用,并测定荷瘤小鼠脾指数、T淋巴细胞的增殖刺激指数、腹腔巨噬细胞的吞噬指数。结果:箬叶多糖3个剂量组对荷瘤小鼠肿瘤的生长都有一定的抑制作用,并能增加小鼠脾指数,促进淋巴细胞转化,提高荷瘤小鼠腹腔巨噬细胞的吞噬百分率和吞噬指数。结论:箬叶多糖在小鼠体内可以抑制肿瘤的生长,并能增强机体免疫功能。Objective：To explore the inhibition of indocalamus tessellatus polysaccharides on tumor growth and its immune regulation.Methods：U14-bearing-mice were used to observe the inhibitory action of indocalamus tessellatus polysaccharides on tumor growth and determine the index of spleen,the proliferation index of T lymphocyte and the phagocytic index of peritoneal macrophage.Results：Three doses of Indocalamus tessellatus polysaccharides showed tumor-inhibitory effects,increased the index of spleen,promoted lymphocyte transformation and increased phagocytic percentage as well as index of peritoneal macrophage.Conclusion：Indocalamus tessellatus polysaccharides can inhibit tumor growth and enhance immune regulation in vivo.

关 键 词：箬叶 多糖 宫颈癌 免疫功能 U14 细胞 

分 类 号：R737.33[医药卫生—肿瘤]