张家口市门诊女性HPV感染与宫颈病变筛查的临床资料分析  

Screening of human papillomavirus infection and cervical lesion in female outpatients of Zhangjiakou City

作　　者：刘晨[1] 王莉[1] 张凡[2] 祝亚猛 

机构地区：[1]武警北京总队医院妇产科,100027 [2]河北北方学院附属第一医院病理科 [3]武警北京总队医院病理科

出　　处：《中国计划生育学杂志》2012年第3期190-192,196,共4页Chinese Journal of Family Planning

基　　金：河北省科技局

摘　　要：目的:了解张家口地区妇产科门诊女性生殖道高危型HPV感染现状及子宫颈上皮瘤样病变(CIN)的发生情况。方法:回顾性收集2010年11月～2011年6月,在河北北方学院附属第一医院妇产科就诊的19～70岁女性筛查资料和临床病理资料。所有调查对象均行子宫颈醋酸肉眼观察、电子阴道镜检查、液基细胞薄层涂片技术子宫颈脱落细胞学检查(LCT)及第二代杂交捕获技术(HC-Ⅱ)检测高危型HPV。对于HPV阳性、未明确诊断意义的不典型鳞状上皮细胞(ASCUS)、LSIL及以上病变者,行电子阴道镜检查,并取活检,进行病理诊断。结果:共调查了2 397例妇女,分为15～24岁、25～29岁、30～34岁、35～39岁、40～44岁、45～49岁和50～70岁年龄组,高危HPV检出率分别为19.5%、21.7%、12.6%、10.8%、11.2%、19.3%和21.0%,组间存在差异(P<0.05);25～29岁组与50～59岁组HPV感染率较高,但两组间HPV感染率无差异(P>0.05)。CINⅠ、CINⅡ和CINⅢ现患率分别为4.2%、1.8%和0.4%,CINⅠ现患率高于CINⅡ和CINⅢ(P<0.05)。HPV感染率随子宫颈病变级别升高呈趋势性增加,无CIN病变的子宫颈HPV感染率为8.7%。结论:张家口地区门诊妇女生殖道HPV高危型感染率较高,且子宫颈病变多处于CIN的早期阶段。Objective：To explore the status of high risk human papillomavirus（HPV） infection and the prevalence rate of cervical intra-epithelial neoplasia（CIN） among female outpatients of Zhangjiakou Cityby.Methods：Women aged 19-70 who conducted visual inspection of cervix with acetic acid（VIA）,electronic colposcopy,liquid-based cervicalcytology（LCT） and Hybrid Capture II（HC-II） between Nov.2010 and June 2011 were recruited.Biopsy under colposcopy pathology was conducted in HPV-positive women and those with atypical squamous cells undetermined significance（ASCUS）,lower-grade squamous intraepithelial lesions（LSIL） LSIL and more serious.Results：A total of 2 397 women recruited were divided into seven groups according to their ages：15-24 years old,25-29 years old,30-34 years old,35-39 years old,40-44 years old,45-49 years old and 50-70 years old.The detection rates of high risk HPV were 19.5%,21.7%,12.6%,10.8%,11.2%,19.3% and 21.0%,showing statistically significant differences（P〈0.05）.The infection rates of high risk HPV in women aged 25-29 and 50-59 were higher,but there was no significant difference between these two groups（P〈0.05）.The prevalence rates of CIN I,CIN II and CIN III were 4.2%,1.8% and 0.4%.That of CIN I was higher those of CIN II and CIN III（P〈0.05）.The infection rate of HPV was increased with the grade of cervical lesions.And the infection rate of HPV was 8.7% in women without CIN.Conclusion：The infection rate of the high risk HPV is higher and themajority of cervical lesions are the low grade of CIN in ZhangJiakou.

关 键 词：人乳头瘤病毒 子宫颈上皮内瘤样病变 现患率 

分 类 号：R737.33[医药卫生—肿瘤]