食管鳞状细胞癌中雌激素受体和p53蛋白的表达及其意义  

Distribution of ER and p53 Protein Accumulation in Human Esophageal Squamous Cell Carcinoma and its Clinical Significance

作　　者：曹巍[1] 常扶保 陈旭峰[3] 王慧珍 郑宗秀[5] 原志庆[5] 

机构地区：[1]新乡医学院病理教研室,河南新乡453003 [2]河南省林县食管癌医院 [3]浙江省肿瘤医院 [4]河南省新乡市中心医院 [5]新乡医学院

出　　处：《肿瘤防治研究》2000年第1期28-30,共3页Cancer Research on Prevention and Treatment

基　　金：河南省自然科学基金! (95 40 2 0 90 0 )

摘　　要：目的　探讨ER和p53蛋白表达与ESCC的临床病理关系。方法　应用免疫组织化学方法检测了ESCC中ER和p53蛋白的表达。结果　 4 7例ESCC中 ,ER阳性者 19例 ,其表达率为4 0 4 % (19 4 7) ;生存期大于 5年组与生存期小于 5年组相比 ,具有显著性差异 (P <0 0 5) ;p53蛋白表达者 2 9例 ,表达率为 6 1 7% (2 9 4 7) ;其阳性率在淋巴结有无转移 ,病人生存期长短之间存在明显差异。ER阳性ESCC的p53蛋白阳性表达率高于ER阴性ESCC ,具有统计学差异。结论　ER阳性的食管癌与p53蛋白表达密切相关。ER及p53蛋白的表达与ESCC的预后密切相关。Objective In order to ascertain relation between clinical pathological features and distribution of estrogen receptor,p53 protein accumulation in esophageal squamous cell carcinoma (ESCC).Methods Immunohisto chemical detection of ER and p53 protein was performed in 47 cases of Linxian esophageal cancer.Results ER positive was identified in 19 of the 47 patients with esophageal cancer.The positive rate for the ER was 40 4%.There was a significant association between ER positive rates in groups survived longer than 5 years and less than 5 years.The p53 protein accumulation was seen in 29(61 7%) cases.Accumulation of p53 protein rate was 50% in group survived longer than 5 years,78 9% in group survived less than 5 years,with a highly significant difference between the two groups ( P <0 05).A significantly higher rate of p53 protein accumulation was found in cases with lymph nodes metastasis (77 2%) than in cases with no lymph nodes metastasis ( P <0 05).ER positive ESCC had a signifiantly higher expression of p53 protein than ER negative ESCC.Conclusion The results demonstrates a consistent relationship between ER- positive tumors and p53 protein accumulation.Measurements of ER and p53 protein accumulation in esophageal cancer have important and practical prognostic implications.

关 键 词：鳞状细胞癌 雌激素受体 P53蛋白 预后 食管肿瘤 

分 类 号：R735.1[医药卫生—肿瘤]