Puerarin decreases hypoxia inducible factor-1 alpha in the hippocampus of vascular dementia rats  

作　　者：Haiqin Wu Huqing Wang Bei Zhang Guilian Zhang Ru Zhang Lingfeng Zhang 

机构地区：[1]Department of Neurology, the Second Affiliated Hospital, Medical College of Xi＇an Jiaotong University, Xi＇an 710004, Shaanxi Province, China

出　　处：《Neural Regeneration Research》2012年第6期421-425,共5页中国神经再生研究（英文版）

摘　　要：In this study, a rat vascular dementia model was established by permanent bilateral common carotid arterial occlusion. Rats were intraperitoneally injected with puerarin 3 days before modeling, for 45 successive days. Results demonstrated that in treated animals hippocampal structures were clear, nerve cells arranged neatly, and cytoplasm was rich in Nissl bodies. The number of cells positive for hypoxia inducible factor-1 alpha, erythropoietin and endothelial nitric oxide synthase was reduced; and the learning and memory abilities of rats were significantly improved. Our experimental findings indicate that puerarin can significantly improve learning and memory in a vascular dementia model, and that the underlying mechanism may be associated with the regulation of the expression of hypoxia inducible factor-1 alpha.In this study, a rat vascular dementia model was established by permanent bilateral common carotid arterial occlusion. Rats were intraperitoneally injected with puerarin 3 days before modeling, for 45 successive days. Results demonstrated that in treated animals hippocampal structures were clear, nerve cells arranged neatly, and cytoplasm was rich in Nissl bodies. The number of cells positive for hypoxia inducible factor-1 alpha, erythropoietin and endothelial nitric oxide synthase was reduced; and the learning and memory abilities of rats were significantly improved. Our experimental findings indicate that puerarin can significantly improve learning and memory in a vascular dementia model, and that the underlying mechanism may be associated with the regulation of the expression of hypoxia inducible factor-1 alpha.

关 键 词：PUERARIN vascular dementia hypoxia-inducible factor-1 alpha ERYTHROPOIETIN endothelial nitric-oxide synthase 

分 类 号：Q749[生物学—分子生物学] S858.316.2[农业科学—临床兽医学]