抗癫痫药物在哺乳期癫痫女性中的合理应用及研究进展  

Rational use of antiepileptic drugs in epileptic mothers during lactation and its research progress

作　　者：陈蕾[1] 周东[1] 

机构地区：[1]四川大学华西医院神经内科,成都610041

出　　处：《解放军医学杂志》2012年第3期264-268,共5页Medical Journal of Chinese People's Liberation Army

摘　　要：癫痫是神经系统的一种常见慢性病,确诊患者通常需持续3～5年规律服用抗癫痫药(AEDs)。生育期女性的癫痫患病率高达0.3%～0.5%,为控制癫痫发作,一些患者在哺乳期也需坚持服用AEDs。母乳是婴儿最理想的天然食物,但几乎所有AEDs均能通过乳汁进入婴儿体内,对其健康存在潜在的危害。因此,患者服用AEDs是否能哺乳,各种类型AEDs对婴儿的影响,哺乳期AEDs的选择等一系列问题都是医生和患者面临的棘手难题。本文从传统和新型AEDs的母体代谢及乳汁排泄率、AEDs在婴儿体内的代谢及影响因素、AEDs对婴儿的影响三方面进行综述,以期指导哺乳期癫痫女性更加合理地选择AEDs,从而最大限度降低或避免AEDs对婴儿的不良影响。The incidence of epilepsy is 0.3% to 0.5% in women at reproductive age.Most women with epilepsy should continue to take antiepileptic drugs（AEDs） even during lactation to control seizure.Although breast milk is the best natural food for babies,almost all AEDs can enter the baby＇s body together with breast milk.Whether patients taking AEDs can breastfeed their babies or not has therefore become a thorny problem for both doctors and patients.This paper aims to review relevant literature in China and abroad to guide epileptic mothers in choosing AEDs rationally during lactation,thereby avoiding or reducing to the utmost extent the adverse effects of AEDs on infants.

关 键 词：癫痫 母乳喂养 

分 类 号：R742.1[医药卫生—神经病学与精神病学]