二氧化硫体内衍生物诱发小鼠骨髓嗜多染红细胞微核的效应  

Micronuclei induced by SO_2 derivatives in mouse bone marrow in vivo

作　　者：孟紫强[1] 桑楠[1] 张波[1] 孟光萌[1] 

机构地区：[1]山西大学生命科学系,环境医学与毒理学研究所太原030006

出　　处：《环境科学学报》2000年第2期239-243,共5页Acta Scientiae Circumstantiae

基　　金：国家自然科学基金! (No.3 9770 63 4) ;山西省自然科学基金

摘　　要：:通过微核试验证明,给小鼠腹腔注射SO2体内衍生物———亚硫酸钠和亚硫酸氢钠混合液(摩尔比:3∶1)可诱发小鼠骨髓嗜多染红细胞(PEC)微核形成,导致微核细胞率显著升高,且呈明确的剂量效应关系,从整体水平证明了SO2是染色体断裂剂和基因毒性因子.结果也指出,SO2衍生物对丝裂霉素C(MMC)诱发PCE微核有促进作用,而对环磷酰胺(CP)诱发微核有抑制效应,表明SO2对阳性致突变剂的影响是复杂的.Micronuclei (MN) induced in the polychromatophilic erythroblasts (PCE) of mouse bone marrow by SO\-2 derivatives the mixture of sodium sulfite and bisulfite (3∶1?mol/mol) were studied in vivo.It showed that the chemicals caused an increase of MN frequaencies in the PCE cells in a dose\|dependent manner.The results also indicated that SO\-2 derivatives (Na\-2SO\-3 and NaHSO\-3) singnificantly inhibited mutagen cyclophosphamide (CP)\|induced MN formation in the PCE cells of mouse bone marrow; however,the chemicals enhanced mutagen Mitomycin C (MMC) \|induced MN formation in mouse PCE cells.These results imply that SO\-2 is a clastogenic and genotoxic agent,but the effects on mutagenesis of different mutagens are various.

关 键 词：二氧化硫 微核 小鼠 骨细胞细胞 污染物质 

分 类 号：X132[环境科学与工程—环境科学] R994.6[医药卫生—毒理学]