^(18)F-脱氧葡萄糖PET/CT显像在卵巢癌术后复发诊断及治疗中的价值  

The Value of ^(18)F-FDG PET/CT in Diagnosis and Treatment of Patients with Postoperative Recurrent Ovarian Cancer

作　　者：谢红军[1] 宋文忠[1] 高海燕[1] 杨年[2] 刘兆辉[1] 

机构地区：[1]四川省人民医院PET/CT中心,四川成都610072 [2]四川省人民医院妇产科,四川成都610072

出　　处：《中国医学影像学杂志》2012年第3期225-228,共4页Chinese Journal of Medical Imaging

摘　　要：目的探讨全身18F-脱氧葡萄糖(FDG)PET/CT显像在卵巢癌术后患者复发诊断和治疗中的价值。资料与方法 46例患者,行全身显像及局部延迟显像;以病灶最大标准摄取值(SUVmax)>2.5伴密度异常为阳性,检测血清糖类抗原-125(CA125)。10个月内随访。结果 60例次全身显像,阳性48例次,30例次延迟显像SUVmax增加大于20%;CA125升高39例次。34例病灶在腹盆腔内,12例伴有其他部位转移。检查后化疗22例次,再手术12例次,放疗8例次,未治疗13例次。切除26处病灶中,25处肿瘤转移,准确率为96.2%。结论 PET/CT发现卵巢癌术后转移灶主要位于腹盆腔内;手术切除病例,CA125明显降低;多灶性病例行全身化疗或局部放疗;CA125正常病例,显像可提前发现转移病灶。Purpose To investigate the value of 18F-fluorodeoxyglucose （FDG） PET/CT in diagnosis and treatment of patients with postoperative recurrent ovarian cancer. Materials and Methods The early and delayed imaging of 18F-FDG PET/ CT was performed in forty-six postoperative patients of ovarian cancer diagnosed pathologically. The lesions were defined as positive if the maximum standardized uptake value （SUVmax） 2.5 in PET. Every patient had the result of carbohydrate antigen 125 （CA125） and was followed-up within 10 months after the examination. Results In the 46 patients, there were 60 examinations in total and 48 were positive. In the delayed imaging, 30 examinations＇ SUVmax increased by more than 20%. There were 39 examinations with increased CA125. The lesions in 34 cases were located within the abdominal and pelvic cavities, while there were metastatic lesions in other locations in 12 cases. After the examinations of PET/CT, 22 patients underwent chemotherapy, 12 patients underwent operation, 8 patients underwent radiotherapy, and 13 patients didn＇t get any treatment. In the 26 lesions which were resected after the PET/CT exam, there were 25 metastases with diagnostic accuracy as high as 96.2%. Conclusion PET/CT shows that the metastasis are mainly located within abdomen and pelvis for the postoperative cases of ovarian cancer. After surgical resection, their CA125 level significantly decreases. Systemic chemotherapy and local radiotherapy are adopted for the multifocal metastasis patients. For the postoperative cases without increased CA125, PET/CT can serve as an important tool to find early lesion.

关 键 词：卵巢肿瘤 肿瘤复发 局部 正电子发射断层显像术 氟脱氧葡萄糖F18 

分 类 号：R737.31[医药卫生—肿瘤] R730.44[医药卫生—临床医学]