Egr-1与TNF-α在口腔扁平苔藓病损中表达的研究  

The study on the expression of Egr-1 and TNF-α in oral lichen planus

作　　者：张新[1] 吕晓丹[2] 漆明[3] 韩恩善[4] 师志云[5] 

机构地区：[1]宁夏医科大学口腔医学院口腔内科,银川750004 [2]石家庄市第二医院口腔科,石家庄050000 [3]宁夏医科大学总医院口腔科,银川750004 [4]宁夏医科大学总医院中心实验室,银川750004 [5]宁夏医科大学总医院病理科,银川750004

出　　处：《重庆医科大学学报》2012年第1期63-66,共4页Journal of Chongqing Medical University

摘　　要：目的:研究早期生长反应基因-1(Early growth response gene-1,Egr-1)和肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)在口腔扁平苔藓(Oral lichen planus,OLP)组织中的表达及其是否存在相关性。方法:采用免疫组织化学法和Westernblot技术检测30例正常口腔黏膜(Normal oral mucosa,NOM)组织与30例OLP组织中Egr-1和TNF-α的表达情况。结果:(1)上皮层中Egr-1、TNF-α在NOM组和OLP组均有表达,两组比较Egr-1表达无统计学意义(P>0.05),TNF-α表达为OLP组高于NOM组(P<0.05);在固有层中Egr-1、TNF-α的表达均为OLP组高于NOM组(P<0.05)。(2)Egr-1与TNF-α的表达量均为OLP组高于NOM组(P<0.05)。(3)在OLP组中Egr-1、TNF-α表达呈正相关(r=0.447,P<0.05)。结论:Egr-1和TNF-α是OLP发病的重要因素之一,Egr-1可能调控TNF-α的过量释放引起OLP的发病;两者的作用机制有待于进一步研究。Objective：To investigate the expression of Egr-1 and TNF-α in normal oral mucosa（NOM） and oral lichen planus（OLP） and their correlation.Methods：Using immunohistochemistry and Western blot technique,the expressions of early growth response gene-1（Egr-1） and tumor necrosis factor-α（TNF-α） in the tissues samples（30 cases of NOM tissues and 30 cases of OLP tissues） were detected.Results：（1）In epithelial lamina Egr-1 and TNF-α had expressed both in NOM and OLP,the expression of Egr-1 was no significant difference in the two groups（P0.05）,the expression of TNF-α in OLP group was significantly higher than that in NOM group（P0.05）;in lamina propria the expression of Egr-1 and TNF-α in OLP group was significantly higher than that in NOM group（P0.05）.（2）The expressed quantity of Egr-1 and TNF-α in OLP group was significantly higher than that in NOM group（P0.05）.（3）The expression of Egr-1 and TNF-α in OLP showed a positive correlation（r=0.447,P0.05）.Conclusion：Egr-1 and TNF-α were one of the most important factor of OLP,TNF-α excess release of OLP onset may be caused by Egr-1 regulation;The mechanism of action remains to be further studied.

关 键 词：口腔扁平苔藓 早期生长反应基因-1 肿瘤坏死因子-Α 

分 类 号：R781.5[医药卫生—口腔医学]