SPARC结构与功能研究进展  

Progress of Structure and Function of SPARC

作　　者：冯丹[1] 蔡建[2] 张颖一[1] 傅强[1] 王雅杰[1] 

机构地区：[1]第二军医大学附属长海医院肿瘤科,上海200433 [2]解放军第150医院普外科,河南洛阳471031

出　　处：《现代生物医学进展》2012年第3期560-562,共3页Progress in Modern Biomedicine

基　　金：上海市重点学科资助项目(B905)

摘　　要：SPARC(secreted protein,acidic and rich in cysteine)是一种具有多样细胞生物学功能、分布广泛的分泌性基质蛋白。具有3个独立模块结构,不同肽段所行使生物学功能不尽相同。除破坏细胞粘附和抑制细胞周期进程外,SPARC还具有调节细胞分化、参与细胞对某些生长因子反应等生理功能。SPARC参与PI3K/AKT、MAPK、Wnt通路的调控,并对β-FGF、VEGF、PDGF、TGFβ等生长因子以及基质蛋白酶具有调节作用。对SPARC功能多样性的深入研究,有助于阐明SPARC组织特异性的作用机制。SPARC（secreted protein,acidic and rich in cysteine）,a well-known secreted extracellular matrix-associated glycoprotein is known to be involved in multiple biological function.SPARC is widely distributed,consisted of three peptides with multi-function.Besides the roles in adhesion and cell cycle,SPARC also plays a role in cell differentiation and interacts with some growth factors.SPARC is involed in several signal pathways,such as PI3K/AKT,MAPK,Wnt.SPARC also can modulate several growth factors,such as β-FGF,VEGF,PDGF,TGFβ and MMPs.It can fully understand the specific mechanisms in different tissues through deepgoing studies of the functions of SPARC.

关 键 词：SPARC 信号转导 生长因子 

分 类 号：Q51[生物学—生物化学] R34[医药卫生—基础医学]