胃腺癌患者舌苔变化及其血清sE-cad水平和临床检验指标的相关性  

Relationships among changes in tongue coating,levels of serum soluble E-cadherin,clinical examination parameters and gastric adenocarcinoma

作　　者：张军峰[1] 吴娟[1] 孙正[2] 张春兵[3] 佟书娟[1] 杨亚平[1] 马宏跃[4] 秦蕾[1] 董伟[1] 詹瑧[1] 

机构地区：[1]南京中医药大学中西医结合学科,江苏省南京市210046 [2]江苏省中医院消化肿瘤外科,江苏省南京市210029 [3]江苏省中医院检验科,江苏省南京市210029 [4]南京中医药大学药学院,江苏省南京市210046

出　　处：《世界华人消化杂志》2012年第3期193-199,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.30973715;No.81001502;江苏省自然科学基金资助项目;No.BK2008461;教育部高等学校博士点基金资助项目;No.20103237110011;江苏高校优势学科建设工程基金资助项目(PAPD);江苏省高校自然科学基金资助项目;No.10KJB360004;南京中医药大学优秀中青年教师支持计划基金资助项目~~

摘　　要：目的:探讨胃腺癌患者和正常人的舌苔形成与血清sE-cad水平的相关性.方法:采用临床病例-对照法,应用ELISA测定266例胃腺癌患者和252例对照人群的血清sE-cad水平,非参数检验分析血清sE-cad水平、临床检验指标和舌苔类型的相关性.结果:胃腺癌组血清sE-cad水平显著高于对照组(P<0.01),术前者血清sE-cad水平显著高于术后者(P<0.05),胃腺癌未转移者血清sE-cad水平显著高于转移者(P<0.05).胃腺癌组血清sE-cad水平表现为白厚苔>白薄苔>黄厚苔>黄薄苔>剥苔,有统计学意义(P<0.05),对照组血清sE-cad水平表现为黄薄苔>黄厚苔>白薄苔>白厚苔>剥苔,但无统计学意义(P>0.05).胃腺癌组临床检验指标异常者比例均高于对照组(P<0.05),特别是总蛋白异常的厚苔、薄苔胃腺癌患者的血清sE-cad水平均高于总蛋白异常的厚苔、薄苔对照组(P<0.05).结论:胃腺癌患者苔质厚薄变化、血清总蛋白和sE-cad水平检测对临床胃腺癌防治可能有重要的临床价值.AIM：To investigate the relationship between serum soluble E-cadherin （sE-cad） levels and changes in tongue coating in patients with gastric adenocarcinoma and healthy controls.METHODS：This was a case-control study involving 266 gastric adenocarcinoma cases and 252 healthy controls.Serum levels of sEcad were measured by ELISA.The correlations among serum sE-cad levels,clinical examination parameters and type of tongue coating were analyzed using nonparametric tests.RESULTS：Serum levels of sE-cad were significantly higher in gastric adenocarcinoma cases than in healthy controls （P 0.01）,in patients before operation than in those after operation （P 0.05）,and in patients with metastasis than in those without metastasis （P 0.05）.The levels of sE-cad were highest in patients with white thick coating,followed by those with white thin coating,yellow thick coating,yellow thin coating and exfoliative coating （P 0.05）,whereas the order in healthy controls was yellow thin coating,yellow thick coating,white thin coating,white thick coating and exfoliative coating （P 0.05）.The proportion of gastric adenocarcinoma cases with abnormal clinical examination parameters was higher than that of healthy controls （P 0.05）.Especially,gastric adenocarcinoma cases with thick and thin coatings and abnormal total protein had higher levels of sE-cad than healthy controls （P 0.05）.CONCLUSION：The changes in thick and thin coatings and levels of total protein and sE-cad in serum can offer clues for diagnosis and treatment of gastric adenocarcinoma.

关 键 词：胃腺癌 舌苔 血清sE-cad 临床检验指标 

分 类 号：R735.2[医药卫生—肿瘤]