乙肝肝硬化血清透明质酸与HBV DNA的相关性  

Correlation between serum hyaluronic acid and HBV DNA levels in patients with hepatitis B-associated cirrhosis

作　　者：金宏慧 李仲平 

机构地区：[1]南华医院肝病科,上海市201399

出　　处：《世界华人消化杂志》2012年第3期229-232,共4页World Chinese Journal of Digestology

摘　　要：目的:探讨乙肝肝硬化患者血清透明质酸与HBV DNA水平的相关性.方法:收集乙肝肝硬化患者144例,其中女性42例,男性102例,平均年龄(54.42±11.53)岁,Child pugh A级42例,Child pugh B级40例,Child pugh C级62例,采用放射免疫法检测血清透明质酸,荧光定量PCR检测血清HBV DNA水平,对血清透明质酸、血清HBV DNA水平进行统计并分析两者之间的关系.结果:随着乙肝肝硬化Child分级的加重,患者的血清透明质酸水平也增高,不同分级之间的差异有统计学意义(174.10μg/L±127.98μg/Lvs421.35μg/L±176.96μg/Lvs903.58μg/L±212.02μg/L,P<0.01).不同Childpugh分级患者的血清HBV DNA水平差异无统计学意义(P>0.05).不同Child pugh分级患者的血清HBV DNA和透明质酸水平无显著相关性(P>0.05).结论:随着患者的Child pugh分级升高,HA水平显著增高,说明HA是反映肝硬化程度的敏感指标;乙肝肝硬化患者HBV DNA与肝硬化程度无显著相关,血清透明质酸与HBV DNA水平之间也无显著相关性,因此抗病毒和抗纤维化治疗对乙肝肝硬化患者同等重要.AIM：To investigate the relationship between serum hyaluronic acid （HA） and hepatitis B virus （HBV） DNA levels in patients with hepatitis B-associated cirrhosis.METHODS：The clinical data for 144 patients diagnosed with hepatitis B-associated cirrhosis were analyzed.There were 42 females and 102 males,and their average age was 54.42 ± 11.53 years.These patients were divided into three groups based on Child-Pugh grade：A,B,and C.Serum HA was determined by radioimmunoassay and serum HBV DNA was determined by fluorescent quantitative PCR.The relationship between serum HA levels and HBV DNA levels was analyzed.RESULTS：Serum levels of HA increased significantly in patients with hepatitis B-associated cirrhosis and positively correlated with the Child-Pugh grade （174.10 μg/L ± 127.98 μg/L vs 421.35 μg/L ± 176.96 μg/L vs 903.58 μg/L ± 212.02 μg/L,all P 0.01）.There were no significant differences in serum HBV DNA levels among the three groups of patients （P 0.05）.Serum HA levels had no significant correlation with serum HBV DNA levels in patients with hepatitis B-associated cirrhosis （P 0.05）.CONCLUSION：HA is a promising marker for hepatic fibrosis in patients with chronic hepatitis B.Serum HBV DNA levels had no significant correlation with liver cirrhosis grade or serum HA levels in patients with hepatitis B-associated cirrhosis.Anti-virus and anti-cirrhosis treatments are equally important for patients with hepatitis B-associated cirrhosis.

关 键 词：乙肝肝硬化 血清透明质酸 乙型肝炎病毒DNA 

分 类 号：R575.2[医药卫生—消化系统]