地佐辛在腹腔镜直肠癌根治术后镇痛中的应用效果  被引量:1

The Analgetic Efficacy of Dezocine Following Laparoscopic Radical Procedure for Rectal Carcinoma

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作  者:张帆[1] 章杭[1] 李丰[1] 

机构地区:[1]杭州市第一人民医院吴山院区麻醉科,浙江杭州310002

出  处:《中国肛肠病杂志》2012年第2期28-30,共3页Chinese Journal of Coloproctology

摘  要:为探讨地佐辛在腹腔镜直肠癌根治术后镇痛中的应用效果与安全性,本研究选择择期行全麻下腹腔镜直肠癌根治术的患者50例,ASA分级Ⅰ~Ⅱ级,随机分为地佐辛组(A组)和曲马多组(B组)各25例。术毕前15min给予负荷剂量,A组注射地佐辛0.1mg/kg,B组注射曲马多2mg/kg。术后病人自控镇痛(PCA),镇痛泵配方:A组地佐辛0.6mg/kg、氟哌利多5mg加生理盐水至100ml,B组曲马多600mg、氟哌利多5mg加生理盐水至100ml,两组均以2ml/h的速度持续静脉泵注,单次剂量为0.5ml,锁定时间15min。比较两组患者术后临床指征、镇痛及镇静效果、PCA按压次数、不良反应发生率、首次排气及排便时间。结果显示,两组术后均无呼吸抑制现象,各临床指征稳定,两组间差异无统计学意义(P〉0.05);术后4h、8h、12h、16h、24h及48h镇痛及镇静效果差异亦无统计学意义(P〉0.05);但A组术后不良反应、PCA按压次数明显少于B组(P〈0.05),且胃肠道功能恢复比B组快(P〈0.05)。结果表明,地佐辛用于术后镇痛安全、有效,与曲马多相比,疗效相当,但用药量少,不良反应少,对胃肠道功能抑制作用低,更适于腹腔镜直肠癌根治术后自控镇痛。The objective of this study was to explore the applicable efficacy and safety of dezocine in the postoperative analgesia of laparoscopic radical procedure for rectal carcinoma. The 50 patients to be subjected to schemed laparoscopic radical procedure for rectal carcinoma under general anesthesia were selected, were of ASA Ⅰ~Ⅱ grade,and divided randomly them into A and B group(i, e dezocine group,and tramadol group,25 cases/per group). The load dosage was given(in A group, injecting 0. lmg/kg of dezocine; in B group,injecting tramadol of 2mg/kg) 15 min before the end of operation; after operation the patients re ceived patient-controlled analgesia(PCA),which the prescription of analgesia dezocine 0.6mg/kg,droperidol 5mg,adding normal saline solution up to 100m pump in A and B group was ; tramadol 600mg, droperidol 5mg,adding normal saline solution up to 100ml,respectively;in both groups with the velocity of 2ml/h con- tinuously intraveinously injection was taken by pump, the dosage of single time is 0. 5ml and lasted for 15rain;then the postoperative clinical symptom and sign, the efficacy of analgesia and sedation, the press times of PCA,the incidence of adverse reaction,the time of exsufflation and defecation at the first time of both groups were compared each other. As results, in both group there was no respiratory inhibition, all clinical symptoms and sign were stable, the difference between both groups had no statistical significance ( P 〉0.05) ;the difference of efficacies in analgesia and sedation at 4,8,12,16,24 and 48h after operation had also no statistical significance( P 〉0. 05) ;but, in A group the incidence of adverse reaction, the press times of PCA were significantly less than that in control group ( P 〈0.05),and the function recovery of gastrointestinal tract was faster than that of B group( P 〈0.05). Results show that compared with tramadol dezocine has similar therapeutic effect,and is of less usage dose and adverse reaction,as well lower inhibition on

关 键 词:地佐辛 腹腔镜直肠癌根治术 术后镇痛 

分 类 号:R735.37[医药卫生—肿瘤]

 

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