热休克蛋白27在食管上皮癌变过程中的表达及其意义  

Expression and Significance of Heat Shock Protein 27 Druing Carcinogenesis of Esophageal Squamous Epithelium

作　　者：陈理明[1] 谢晓原[1] 李晓洁[1] 刘坚鹏[1] 

机构地区：[1]汕头大学医学院第一附属医院肿瘤科,广东省汕头,515041

出　　处：《中国基层医药》2012年第5期649-650,I0001,共3页Chinese Journal of Primary Medicine and Pharmacy

基　　金：基金项目：广东省汕头市重点科技计划项目（汕府科[2010]63.181

摘　　要：目的了解热休克蛋白27（HSP27）在食管鳞癌、癌旁组织和切缘正常食管黏膜中的表达，分析其表达差异，并探讨其与食管癌发生发展的关系。方法应用免疫组化Envision二步法，观察HSP27在食管鳞癌、癌旁组织和切缘正常食管黏膜中的表达，并比较其间是否存在差异。结果食管鳞癌、癌旁组织和切缘正常食管黏膜中HSP27的阳性表达率分别为73．3％、53．5％和25．3％；HSP27在食管鳞癌中的阳性表达率高于在癌旁组织（P〈0．05），在癌旁组织中的阳性表达率高于在切缘正常食管黏膜（P〈0．001）。随着食管鳞癌高、中、低分化程度的不同，HSP27的阳性表达率逐渐降低，但差异无统计学意义（P〉0．05）。结论HSP27可能与食管鳞癌的发生发展有关。Objective To investigate the expression-of heat shock protein 27 （HSP27） in esophageal squamous carcinoma,mucosa adjacent to carcinoma and normal esophageal mucosa,and its relationship with the carcinogenesis of esophageal carcinoma. Methods The expression of HSP27 was observed in 86 specimens from esophageal squamous carcinoma,86 from mucosa adjacent to carcinoma and 75 from normal esophageal mucosa by immunohistochemistry. Results The expression of HSP27 in esophageal squamous carcinomas was higher than those in mucosa adjacent to carcinoma（ P 〈 0.05 ） ; the expression of HSP27 in mucosa adjacent to carcinoma was higher than those in normal esophageal mucosa（ P 〈 0. 001 ）. There was no significant difference in the expression of HSP27 in esophageal squamous carcinomas with different differentiation degree （ P 〉 0.05 ）. Conclusion. Expression of HSP27 was associated with the carcinogenesis of esophageal squamous carcinoma.

关 键 词：食管肿瘤 热休克蛋白27 免疫组织化学 

分 类 号：R735.1[医药卫生—肿瘤]