分子标志物在胶质瘤诊断和治疗中的意义  

The significance of molecular markers in diagnosis and treatment of glioma

作　　者：杨林[1,2] 郑佳坤[1] 杨立业[1] 

机构地区：[1]潮州市中心医院神经外科,广东潮州521021 [2]汕头大学医学院,广东汕头515040

出　　处：《分子诊断与治疗杂志》2012年第2期115-119,共5页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金(81101329);广东省医学科研基金(A2009781;B2010348);广东省社会发展计划(2011B031800329)

摘　　要：胶质瘤是发生率最高的颅内恶性肿瘤。不同类型的胶质瘤存在着不同的发病机制,即相同病理类型的胶质瘤的分子病因可能存在差异,并且对放疗或化疗的反应也不尽相同。人们试图根据不同的分子生物学表现将胶质瘤分成不同的亚型,同时发现某些分子标志可用于评估胶质瘤预后及预测胶质瘤对治疗的反应。Glioma was the most common and aggressive brain tumor. With the development of molecular research on the pathogenesis of glioma, scientists found that the causes of distinct gliomas were different. Meanwhile, the reaction of patients to chemical and radiological therapy were different. Therefore, researchers have been trying to distinguish the subtype of glioma by its molecular characters. Recently, some molecular markers related to prognosis and therapy reactions of glioma were identified and accepted by most scientists.

关 键 词：胶质瘤 分子生物学标志 诊断 个体化治疗 

分 类 号：R739.4[医药卫生—肿瘤]