Her2/Neu和EGFRvⅢ与乳腺癌发生及浸润的相关性研究  

Study on the relationship between the expression of Her2/Neu and EGFRvⅢ and the pathogenesis of the occurring and the invasion in the breast carcinoma

作　　者：杨永滨[1] 黄建霞[2] 宋文娅[1] 刘海杰[2] 许苗苗[1] 薛娟[1] 

机构地区：[1]河北大学基础医学院,河北保定071000 [2]河北大学附属医院(临床医学院),河北保定071000

出　　处：《医学研究与教育》2012年第1期21-24,共4页Medical Research and Education

基　　金：河北省2010年科技支撑计划项目(102761101);河北省中医药管理局科学技术研究课题(2008071);河北大学博士基金(2011213);河北大学大学生科技创新项目(2011099)

摘　　要：目的探讨表皮生长因子受体2型(Her2/Neu)和表皮生长因子受体3型突变体(EGFRvⅢ)在乳腺癌发生及其浸润过程中的作用。方法采用免疫组织化学染色法(SP法)检测30例正常乳腺组织(NB)、导管原位癌(DCIS)和乳腺浸润性导管癌(IDCNOS)各50例石蜡标本中Her2/Neu和EGFRvIII的表达情况。结果 Her2/Neu和EGFRvⅢ在NB、DCIS和IDCNOS组中的阳性表达率均呈上升趋势,且差异均有显著性意义(P<0.01)。IDCNOS组中EGFRvⅢ的表达水平明显高于DCIS组(P<0.01)。各组乳腺组织中Her2/Neu和EGFRvⅢ的表达情况呈正相关(r=0.597,P<0.001)。结论 Her2/Neu和EGFRvⅢ均可能参与乳腺癌的发生,且EGFRvⅢ可能在乳腺癌的浸润过程中起重要作用。Objective To discuss the relationship between the expression of Her2/Neu and EGFRvlII and the pathogenesis of the occurring and the invasion in the breast carcinoma. Methods The expressions of Her2/ Neu and EGFRvlII were studied by S-P immunohistochemical staining in the paraffin embedded specimens, 30 cases of the normal breast（NB）, 50 cases of ductal carcinoma in situ（DCIS）and 50 cases of invasive ductal carcinoma, no otherwise specified（IDCNOS）. Results The significant increasing trend of the positive expression was observed in both Her2/Neu and EGFRvlII among the group ofNB, DCIS,and IDCNOS（p〈0.01）.The higher expression of EGFRvlII was observed in IDCNOS than DCIS（p〈0.01）. The postive correlation was found between the expression of Her2/Neu and EGFRvlII in the groups ofNB, DCIS and IDCNOS（r = 0.597, P〈 0.001）. Conclusion It seems that both Her2/Neu and EGFRvlII are related to the occurring of the breast carcinoma, and EGFRvlII might play an important role in the pathogenesis of the invasion.

关 键 词：乳腺癌 表皮生长因子受体2型 表皮生长因子受体3型突变体 机制 

分 类 号：R73[医药卫生—肿瘤]