Modeling sarcomagenesis using multipotent mesenchymal stem cells  

作　　者：Rene Rodriguez Ruth Rubio Pablo Menendez 

机构地区：[1]Stem Cells, Development ＆ Cancer Laboratory, Pfizer- University of Granada- Andalusian Government Centre for Genomicsand Oncological Research （GENyO）, Parque Tecnol6gico de Ciencias de la Salud, Avda de la Ilustraci6n 14, Granada, 18007,Granada, Spain

出　　处：《Cell Research》2012年第1期62-77,共16页细胞研究（英文版）

摘　　要：Because of their unique properties, multipotent mesenchymal stem cells （MSCs） represent one of the most prom- ising adult stem cells being used worldwide in a wide array of clinical applications. Overall, compelling evidence supports the long-term safety of ex vivo expanded human MSCs, which do not seem to transform spontaneously. However, experimental data reveal a link between MSCs and cancer, and MSCs have been reported to inhibit or promote tumor growth depending on yet undefined conditions. Interestingly, solid evidence based on transgenic mice and genetic intervention of MSCs has placed these cells as the most likely cell of origin for certain sarcomas. This research area is being increasingly explored to develop accurate MSC-based models of sarcomagenesis, which will be undoubtedly valuable in providing a better understanding about the etiology and pathogenesis of mesenchymal cancer, eventually leading to the development of more specific therapies directed against the sarcoma-initiating cell. Unfortunately, still little is known about the mechanisms underlying MSC transformation and further studies are required to develop bona fide sarcoma models based on human MSCs. Here, we comprehensively review the exist- ing MSC-based models of sarcoma and discuss the most common mechanisms leading to tumoral transformation of MSCs and sarcomagenesis.

关 键 词：multipotent mesenchymal stem cells adipose-derived stem cell SARCOMA sarcoma models fusion genes cancerstem cell sarcoma-initiating cell 

分 类 号：Q813.11[生物学—生物工程] S852.651[农业科学—基础兽医学]