血清t-PSA及f-PSA/t-PSA比值在前列腺癌诊断中的价值  

Diagnostic value of serum t-PSA and f-PSA/t-PSA in prostate cancer

作　　者：叶波[1] 张珂[1] 宋晓玉[1] 

机构地区：[1]四川省肿瘤医院,成都610041

出　　处：《检验医学与临床》2012年第6期651-652,共2页Laboratory Medicine and Clinic

摘　　要：目的探讨血清总前列腺特异性抗原(t-PSA)及游离前列腺特异性抗原(f-PSA)/t-PSA比值在前列腺癌(PCa)诊断中的价值。方法对96例PCa与50例前列腺增生(BPH)患者进行血清t-PSA、f-PSA检测并计算f-PSA/t-PSA比值。结果 PCa与BPH两组患者间t-PSA和f-PSA/t-PSA比值差异有统计学意义(P<0.05)。当t-PSA介于4.0～10.0ng/mL,两组患者间t-PSA差异无统计学意义(P>0.05),而f-PSA/t-PSA比值差异有统计学意义(P<0.05),而且f-PSA/t-PSA比值分别为0.10、0.16、0.25时,对PCa诊断的灵敏度分别为39.1%、67.3%、94.5%;特异性分别为92.5%、85.0%、52.4%。结论血清t-PSA及f-PSA/t-PSA比值在PCa诊断中有重要临床价值。Objective To investigate the diagnostic value of serum t-PSA and f-PSA/t-PSA in prostate cancer（PCa）.Methods Serum t-PSA and f-PSA/t-PSA of 96 patients with prostatic cancer and 50 patients with benign prostate hyperplasia（BPH） were measured simultaneously.Results The difference of t-PSA and f-PSA/t-PSA had statistical significance between PCa and BPH groups（P0.05）.When the serum t-PSA was between 4.0-10.0 ng/mL,the difference had no statistical significance between PCa and BPH groups（P0.05）,but f-PSA/t-PSA had statistical significance between PCa and BPH groups（P0.05）.And when f-PSA/t-PSA was 0.10,0.16,0.25 respectively,the sensitivities for diagnosing PCa were 39.1%,67.3%,94.5% respectively,the specificities of them were 92.5%,85.0%,52.4% respectively.Conclusion The serum t-PSA and f-PSA/t-PSA have important clinical significances for the diagnosis of PCa.

关 键 词：前列腺癌 前列腺增生 前列腺特异性抗原 

分 类 号：R737.25[医药卫生—肿瘤]