Allo-hematopoietic stem cell transplantation is a potential treatment for a patient with a combined disorder of hereditary spherocytosis  

作　　者：ZHANG Xiao-hui FU Hai-xia XU Lan-ping LIU Dai-hong CHEN Huan HAN Wei CHEN Yu-hong WANG Feng-rong WANG Jing-zhi WANG-Yu ZHAO Ting LIU Kai-yan HUANG Xiao-jun 

机构地区：[1]Peking University People's Hospital,Peking University Institute of Hematology,Beijing 100044,China

出　　处：《Chinese Medical Journal》2012年第5期947-950,共4页中华医学杂志（英文版）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China （No. 30770911 and No. 81070449） ; the Science Foundation of Beijing City in China （No. 7112139）.

摘　　要：Both human hereditary spherocytosis （HS） and chronic myelogenous leukemia （CML） are life threatening. Herein we have reported the case of a woman with a combined disorder of HS and CML who underwent the matched sibling allogeneic stem cell transplantation. The complete donor erythroid cells were obtained. The red blood cell counts significantly improved throughout life comparing with pre-hematopoietic stem cell transplantation （HSCT）. Reticulocyte counts normalized, and BCR-ABL was cleared away. The total bilirubin level was also corrected in this recipient. Our case is a rare example with a combined disorder of HS and CML following allogeneic stem cell transplantation. HS was not a contraindication for patient in the matched sibling transplant setting.Both human hereditary spherocytosis （HS） and chronic myelogenous leukemia （CML） are life threatening. Herein we have reported the case of a woman with a combined disorder of HS and CML who underwent the matched sibling allogeneic stem cell transplantation. The complete donor erythroid cells were obtained. The red blood cell counts significantly improved throughout life comparing with pre-hematopoietic stem cell transplantation （HSCT）. Reticulocyte counts normalized, and BCR-ABL was cleared away. The total bilirubin level was also corrected in this recipient. Our case is a rare example with a combined disorder of HS and CML following allogeneic stem cell transplantation. HS was not a contraindication for patient in the matched sibling transplant setting.

关 键 词：hereditary spherocytosis allogeneic stem cell transplantation  chronic myelogenous leukemia 

分 类 号：TS207.4[轻工技术与工程—食品科学] Q25[轻工技术与工程—食品科学与工程]