肿瘤坏死因子-α在卵巢肿瘤患者腹水中的表达及意义  

Expression of tumor necrosis factor-or in ovarian carcinoma ascites and its meaning

作　　者：陈媛媛[1] 岳天孚[1] 

机构地区：[1]天津医科大学总医院妇产科,300052

出　　处：《国际生物医学工程杂志》2012年第1期50-52,共3页International Journal of Biomedical Engineering

摘　　要：目的探讨卵巢肿瘤患者腹水中肿瘤坏死因子-a（TNF-a）与卵巢癌之间的关系，探讨其对腹水性质鉴别的价值。方法采用酶联免疫吸附法（ELISA）检测59例卵巢上皮性肿瘤、9例原发性腹膜癌、6例卵巢子宫内膜异位囊肿患者腹水TNF-a水平。结果腹水TNF-a水平在卵巢恶性上皮性肿瘤、卵巢交界性肿瘤、原发性腹膜癌中的水平明显高于卵巢良性上皮性肿瘤、卵巢子宫内膜异位囊肿，且与肿瘤的恶性行为包括临床分期、组织分化程度、淋巴转移及腹水量等有关。结论腹水TNF-a对诊断卵巢癌有较高的敏感性和特异性，可能成为卵巢恶性肿瘤的标志物。Objective To investigate the relationship of ovarian cancer and the ascites levels of TNF-a, and to determine the value of elevated TNF-a ascites level on discriminating the feature of ascites. Methods Ascites levels of TNF-a of 59 specimens of epithelial ovarian tumor, 9 specimens of peritoneal primary serous papillary carcinoma （PPSPC） and 6 specimens of endometriosis cyst were detected via ELISA. Results Ascites levels of TNF-a of patients with EOC, PPSPC, BOT were significantly higher than those with BET and EM, and they were related to the clinical stage, tissue differentiation, lymph node metastasis and volume of ascites. Conclusion Aseites levels of TNF-a have the high sensitivity and specificity for diagnosis of ovarian cancer. It might be the tumor marker of ovarian cancer.

关 键 词：肿瘤坏死因子-A 肿瘤坏死因子受体I 酶联免疫吸附法 卵巢肿瘤 

分 类 号：R737.31[医药卫生—肿瘤]