食管癌术后辅助治疗的Meta分析  

A Meta Analysis of Adjuvant Therapy for Esophageal Cancer Postoperation

作　　者：毛伟敏[1] 程蕾[1] 

机构地区：[1]浙江省肿瘤医院浙江省胸部肿瘤诊治技术研究重点实验室,浙江杭州310022

出　　处：《肿瘤学杂志》2012年第2期94-99,共6页Journal of Chinese Oncology

摘　　要：[目的]探讨食管癌术后辅助治疗的价值。[方法]收集1995年至2011年期间发表的关于食管癌术后辅助治疗的随机对照研究文章,利用Stata12.0软件进行Meta分析。[结果]与单纯手术相比,术后辅助化疗患者的3年无进展生存率相对危险度（RR）为1.225（95%CI：1.012~1.482,P=0.037）,差异有统计学意义。而3、5年总生存率的RR值分别为0.899（95%CI：0.797～1.016,P=0.087）,1.183（95%CI：0.97～1.442,P=0.098）,差异无统计学意义。同样,与单纯手术相比,术后辅助放疗患者的3年总生存率的RR值为0.935（95%CI：0.879～0.994,P=0.033）,差异有统计学意义。而5年总生存率的RR值为0.988（95%CI：0.821～1.188,P=0.897）,差异无统计学意义。Begg’s与Egger试验检测P值均大于0.05,不存在发表偏倚。[结论]术后辅助化疗能延长食管癌患者术后的3年无进展生存率,术后辅助放疗不利于延长食管癌患者的3年总生存率。[Purpose] To investigate the value of adjuvant therapy for esophageal cancer postoperation.[Method] randomized control study articles about adjuvant treatment after esophagectomy from 1995 to 2011 were collected,and Stata12.0 software was used for Meta analysis.[Reasults] Compared with patients undergoing surgery alone,the 3-year progress free survival（PFS） in patients with adjuvant chemotherapy was significantly different,with RR 1.225（95%CI：1.012～1.482,P=0.037）.But 3-,5-year overall survival rates（OS） with RR 0.899（95%CI：0.797～1.016,P=0.087） and 1.183（95%CI：0.97～1.442,P=0.098）,respectively.3-year OS of adjuvant radiation patients was significantly different with that of the patients with surgery alone,RR0.935（95%CI：0.879～0.994,P=0.033）.But 5-year OS with RR 0.988（95%CI：0.821～1.188,P=0.897）.P values of Begg＇s and Egger test were greater than 0.05,indicating there was no publication bias in the study.[Conclusion] Postoperative adjuvant chemotherapy can improve the 3-year PFS in patients with esophageal cancer after surgery,while postoperative adjuvant radiation does not improve 3-year OS.

关 键 词：食管肿瘤 辅助化疗 辅助放疗 META分析 

分 类 号：R735.1[医药卫生—肿瘤]