肿瘤干细胞在肿瘤转移中作用与相关机制的研究进展  

The effect and related mechanism of cancer stem cell in tumor metastasis:new perspective and progress

作　　者：朱玉珍[1] 马雨水[2] 符达 

机构地区：[1]同济大学附属同济医院消化内科,上海200065 [2]上海复旦大学附属中山医院消化科,上海200032

出　　处：《基础医学与临床》2012年第4期457-460,共4页Basic and Clinical Medicine

基　　金：中国博士后基金(20100480542)

摘　　要：目前国内外对肿瘤转移的机制已进行了系统而深入的探索。随着肿瘤干细胞概念的提出和相关领域的深入研究,肿瘤干细胞作为肿瘤转移的最佳候选细胞的观点正逐渐被人们接受。目前和肿瘤转移过程相关的分子细胞机制包括:上皮间质转变(EMT)、肿瘤微环境及血管生成机制等。近年来许多研究成果显示上述机制在肿瘤干细胞转移过程中起到不可低估的作用。本文就肿瘤干细胞转移相关机制的进展做一简要综述。Recently,increasing evidences suggest that cancer stem cells（CSCs） are potential candidates for mediating metastatic progression.However,the role of CSC in multistage cancer progression,particularly with respect to metastasis,has not been well-defined.Studies have indicated the important role of Epithelial-mesenchymal transition（EMT）,tumor microenvironment and angiogenesis in regulating cancer metastasis.Current research has also highlighted the above related mechanism in mediating CSC metastasis.The purpose of this review is to discuss the recent advances in the field of CSC in metastasis and related mechanism.

关 键 词：肿瘤干细胞 转移 上皮间质转变 微环境 血管生成 

分 类 号：R730.2[医药卫生—肿瘤]