阿维菌素缓释纳米粒子的制备及其性能研究  

Preparation and properties of nanoparticles for controlled release of avermectin

作　　者：姜官鑫[1] 沈国清[1] 朱鸿林[1] 赏国锋[1] 王亭亭[1] 

机构地区：[1]上海交通大学农业与生物学院,农业部都市农业南方重点开放实验室,上海200240

出　　处：《北京化工大学学报（自然科学版）》2012年第2期84-88,共5页Journal of Beijing University of Chemical Technology(Natural Science Edition)

基　　金：公益性行业(农业)科研专项(200903056);上海市科委科技攻关项目(08dz1900404);上海市科技兴农推广项目(沪农科推字2010第4-5号)

摘　　要：以β-环糊精为载体,用共沉淀法制备了阿维菌素缓释纳米粒子,并对其制备工艺、缓释性能和防紫外光降解作用进行了研究。结果表明,所制备的纳米粒子外观呈球状,平均粒径在50～120 nm之间,β-环糊精对阿维菌素具有良好的包合作用,包合率最高可达65.82%;阿维菌素缓释纳米粒子与其原药相比缓释效果明显,并具有良好的防紫外光降解的作用,在300 min内与原药相比降解缓慢。纳米粒子在96 h后才释放出94.20%的阿维菌素,其累积释放动力学方程为Ra=-88.4348e-0.1032t+86.0599,符合一级动力学释放模型。Nanoparticles for controlled release of avermectin have been prepared usingβ-cyclodextrin as a carrier by a co-precipitation method. The preRaration process, release and UV-shielding properties of avermectin-loaded nano- particles were also investigated. The nanoparticles had a spherical appearance with a diameter of 50 - 120 nm. The highest inclusion efficiency obtained was 65.82%. The controlled release properties of the nanoparticles were clearly demonstrated： 98.04% of avermectin was released from a dialysis bag containing free avermectin after 18 hours, whereas after 96 hours, only 94.20% of avermectin was released from a dialysis bag containing the nanopartieles. The UV-shielding properties of the nanoparticles also had a beneficial effect on the stability of avermectin. In 300 minutes, free avermectin itself decomposed completely under UV light, while avermeetin incorporated in the nanop- articles decomposed more slowly. The accumulative release corresponded to a zero-order kinetics model, with the kinetic equation being Ra = - 88. 4348e -0,032, ＋ 86. 0599.

关 键 词：阿维菌素 Β-环糊精 纳米粒子 缓释性能 动力学方程 

分 类 号：TQ314[化学工程—高聚物工业] S435[农业科学—农业昆虫与害虫防治]