乌司他丁联合抗生素治疗急性胰腺炎致多器官功能损害40例  

Observation of curative effects of Ulinastatin combined with antibiotics in treatment of 40 patients with acute pancreatitis induced multiple organ impairment

作　　者：金献玉 汪霄[2] 

机构地区：[1]浙江省富阳市妇幼保健院内科,浙江富阳311400 [2]浙江大学医学院附属第一医院ICU室

出　　处：《中国现代医生》2012年第10期72-73,75,共3页China Modern Doctor

摘　　要：目的评价乌司他丁联合抗生素治疗急性胰腺炎致多器官功能损害的效果。方法将80例患者随机分2组(各40例),均给予禁食、营养支持与抗生素治疗,治疗组同时给予静脉滴注乌司他丁。结果治疗前两组患者的AMS、ALT、和CRP值无统计学差异;治疗后两组患者AMS分别为(18.5±2.5)IU/L和(22.4±3.3)IU/L,ALT分别为(31.6±4.8)U和(36.3±5.5)U,Cr分别为(72.1±7.2)μmol/L和(85.3±11.5)μmol/L,CRP分别为(6.4±2.6)mg/L和(8.3±3.4)mg/L,差异均有高度统计学意义(P均<0.01)。结论乌司他丁联合抗生素治疗急性胰腺炎致多脏器功能损害效果好,值得临床推广应用。Objective To evaluate the effects of ulinastatin combined with antibiotics in the treatment of acute pancreatitis. Methods Eighty patients were randomly divided into two groups （40 patients in each group） and were given fasting, nu- tritional support and antibiotic treatment. At the same time, the treatment group was also given the intravenous infusion of ulinastatin. Results Before the treatment, the two groups of patients had no significant differences in AMS, ALT and CRP values. After the treatment, AMS of the two groups of patients was （18.5±2.5） IU/L and （22.4±3.3） IU/L respectively, ALT was （31.6±4.8） U and （36.3±5.5） U respectively, Cr was （72.1±7.2） μmol/L and （85.3±11.5） μmol/L respectively, CRP was （6.4±2.6） mg/L and （8.3±3.4） mg/L respectively, with statistical differences for all （P 〈 0.01）. Conclusion Ulinastatin com- bined with antibiotics in the treatment of acute pancreatitis-induced multiple organ impairment has good effects, thereby worthy of clinical promotion and application.

关 键 词：急性胰腺炎 多脏器功能损害 血淀粉酶 谷丙转氨酶 肌酐 反应蛋白 乌司他丁 

分 类 号：R576[医药卫生—消化系统]